Acanthoic Acid Inhibits LPS-Induced Inflammatory Response in Human Gingival Fibroblasts

被引：20
|
作者：
Wei, Cai [1 ]
Tan, Chee Keong [2 ]
He Xiaoping [1 ]
Jiang Junqiang [2 ]
机构：
[1] Luzhou Med Coll, Stomatol Hosp, Dept Prosthodont, Luzhou 646000, Sichuan Provinc, Peoples R China
[2] Luzhou Med Coll, Stomatol Hosp, Dept Oral Med, Luzhou 646000, Sichuan Provinc, Peoples R China
来源：
INFLAMMATION | 2015年 / 38卷 / 02期
关键词：
acanthoic acid; human gingival fibroblasts; cytokine; NF-kappa B; TLR4; NF-KAPPA-B; CYTOKINE PRODUCTION; GENE-EXPRESSION; MACROPHAGES; PROTECTS; SUPPRESSION; ACTIVATION; KOREANUM; MICE; IL-8;
D O I：
10.1007/s10753-014-0051-7
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Periodontitis is a chronic disease that affects the gums and destroys connective tissue. Acanthoic acid (AA), a diterpene in Acanthopanax koreanum, has been reported to have anti-inflammatory activities. The aim of this study was to investigate the anti-inflammatory effects of AA on lipopolysaccharide (LPS)-induced inflammatory response in human gingival fibroblasts (HGFs). HGFs were treated with Porphyromonas gingivalis LPS in the presence or absence of AA. The production of inflammatory cytokines IL-8 and IL-6 were measured by ELISA. The expression of NF-kappa B and TLR4 were detected by Western blotting. The results showed that AA inhibited LPS-induced IL-8 and IL-6 production in a dose-dependent manner. In addition, AA inhibited LPS-induced TLR4 expression and NF-kappa B activation. In conclusion, AA inhibits LPS-induced inflammatory response in HGFs through inhibition TLR4-mediated NF-kappa B signaling pathway.
引用
收藏
页码：896 / 901
页数：6
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