Facile Synthesis of Surfactant-Free Au Decorated Hollow Silica Nanoparticles for Photothermal Applications

被引：7

作者：

Seo, Ju Ri ^{[1
]}

Choi, Hyung Woo ^{[2
]}

Kim, Da Eun ^{[1
]}

Park, Da Yeon ^{[1
]}

Kim, Eun-Joong ^{[2
]}

Chung, Bong Geun ^{[3
]}

机构：

[1] Sogang Univ, Dept Biomed Engn, Seoul 04107, South Korea

[2] Sogang Univ, Res Ctr, Seoul 04107, South Korea

[3] Sogang Univ, Dept Mech Engn, Seoul 04107, South Korea

来源：

MACROMOLECULAR RESEARCH | 2018年 / 26卷 / 12期

基金：

新加坡国家研究基金会;

关键词：

hollow silica nanoparticle; gold nanocomposite; photothermal effect; pH-responsive drug release; MESOPOROUS SILICA; HYALURONIC-ACID; GOLD NANOPARTICLES; DRUG-DELIVERY; THERAPY; COMBINATION; DOXORUBICIN; CONJUGATE;

D O I：

10.1007/s13233-018-6143-8

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

We report herein a novel surfactant-free synthetic approach for hollow silica nanoparticles (HSN) loaded with Au nanocomposites (Au-HSN) to enhance photothermal properties. Transmission electron microscopy and elemental analysis confirmed the uniform HSN of Au nanoparticles. UV-vis spectroscopy and Fourier transform infrared spectroscopy were performed to demonstrate the dopamine (DA)-hyaluronate (HA) coating on Au-HSN. These nanocomposites dramatically increased up to 48 degrees C within few seconds under near-infrared irradiation. In addition, these Au-HSN/DA-HA nanoparticles showed the excellent endocytosis against cancer cells without any cytotoxicity. Therefore, it could be a powerful nanocarrier for tumor targeting and photothermal therapy applications.

引用

页码：1129 / 1134

页数：6

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