Enantioselective Synthesis of Cyclobutylboronates via a Copper-Catalyzed Desymmetrization Approach

被引：96

作者：

Guisan-Ceinos, Manuel ^{[1
]}

Parra, Alejandro ^{[1
]}

Martin-Heras, Victor ^{[1
]}

Tortosa, Mariola ^{[1
]}

机构：

[1] Univ Autonoma Madrid, Madrid, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2016年 / 55卷 / 24期

基金：

欧洲研究理事会;

关键词：

asymmetric catalysis; boron; copper; cyclobutanes; cyclobutenes; COPPER(I)-CATALYZED REACTION; CYCLOBUTANE DERIVATIVES; 2+2 PHOTOCYCLOADDITIONS; HYDROBORATION; ARYL; LIGANDS; DIPHOSPHINITE; CYCLOADDITION; VINYLARENES; ALKENES;

D O I：

10.1002/anie.201601976

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The first catalytic enantioselective synthesis of cyclobutylboronates, by using a chiral copper(I) complex, is reported. A broad variety of cyclobutanes have been prepared with consistently high levels of diastereo- and enantiocontrol. Moreover, this method constitutes the first report of an enantioselective desymmetrization of meso-cyclobutenes to prepare chiral cyclobutanes.

引用

页码：6969 / 6972

页数：4

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