Identification and PEP Inhibitory Activity of Acetophenone Glucosides from the Clove Buds (Syzygium aromaticum)

被引：16
作者：
Han, Ah-Reum
Paik, Young-Sook [1 ]
机构：
[1] Kyung Hee Univ, Dept Appl Chem, Yongin 446701, South Korea
来源：
JOURNAL OF THE KOREAN SOCIETY FOR APPLIED BIOLOGICAL CHEMISTRY | 2010年 / 53卷 / 06期
关键词：
acetophenone glucoside; prolyl endopeptidase inhibitor; Syzygium aromaticum; ENDOPEPTIDASE; LEAVES; CHROMONES; PERRY;
D O I：
10.3839/jksabc.2010.129
中图分类号：
TS2 [食品工业];
学科分类号：
0832 ;
摘要：
Two new acetophenone glucosides, 2,6-dihydroxy-4-methoxyacetophenone 3-C-beta-D-glucoside (1) and 2,6-dihydroxy-4-methoxyacetophenone 3-C-beta-D-(6'-O-galloyl)glucoside (2), together with three known compounds, eugenin (3), 8-C-glucosylnoreugenin (4), and gallic acid (5) were isolated from the EtOAc soluble fraction of the MeOH extract of clove buds (Syzygium aromaticum). Of these, compound 2 showed significant prolyl endopeptidase inhibitory activity with IC(50) value of 17.2+/-1.1 mu M, suggesting it may have potential use against memory impairment and cognitive decline.
引用
收藏
页码：847 / 851
页数：5
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