Asymmetric reduction of acetophenone with calcium-alginate-entrapped Baker's yeast in organic solvents

被引：45

作者：

Griffin, DR ^{[1
]}

Yang, FX ^{[1
]}

Carta, G ^{[1
]}

Gainer, JL ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem Engn, Charlottesville, VA 22903 USA

来源：

BIOTECHNOLOGY PROGRESS | 1998年 / 14卷 / 04期

关键词：

D O I：

10.1021/bp9800586

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Baker's yeast cells entrapped in alginate beads are shown to catalyze reactions in organic solvents when a cofactor regeneration scheme is implemented. This study focused on the reduction of acetophenone to 1-phenylethanol, using baker's yeast as well as a cosubstrate to regenerate the cofactor. The product is a chiral alcohol, and it was desired to maintain a high enantiomeric excess. The effects of parameters such as the addition of a cosubstrate, water content, fermentation time, buffer pH, and bead diameter have been investigated Such a general process may be quite useful when single enantiomers are needed, as well as for the production of other chemicals.

引用

页码：588 / 593

页数：6

共 50 条

[41] NUTRIENTS ALONG WITH CALCIUM IN GLUCOSE FEED ENHANCE THE LIFE OF ALGINATE ENTRAPPED YEAST-CELLS [J].

ARASARATNAM, V .

PROCESS BIOCHEMISTRY, 1994, 29 (04) :253-256

[42] Highly regio- and enantioselective reduction of 1-chloro-2,4-alkanediones using baker's yeast: Effects of organic solvents as additives [J].

Cui, JN ;

Teraoka, R ;

Ema, T ;

Sakai, T ;

Utaka, M .

TETRAHEDRON LETTERS, 1997, 38 (17) :3021-3024

[43] Asymmetric reduction of acetophenone catalyzed by yeast cells and promotion effect of resin adsorption on the reaction [J].

Yang, ZH ;

Yao, SJ ;

Zhao, J .

CHINESE JOURNAL OF CATALYSIS, 2005, 26 (10) :895-899

[44] Integration of Enzyme, Strain and Reaction Engineering to Overcome Limitations of Baker's Yeast in the Asymmetric Reduction of α-Keto Esters [J].

Kratzer, Regina ;

Egger, Sigrid ;

Nidetzky, Bernd .

BIOTECHNOLOGY AND BIOENGINEERING, 2008, 101 (05) :1094-1101

[45] Biocatalytic Asymmetric Synthesis of Danshensu Borneol Ester by Baker's Yeast [J].

Kuang, Xin-Mou ;

Sun, Ying ;

Bai, Ya-Jun ;

Nan, Ye-Fei ;

Zheng, Xiao-Hui .

Jingxi Huagong/Fine Chemicals, 2018, 35 (06) :987-991

[46] A study of Baker's yeast reduction of piperidone-carboxylates [J].

Willert, M ;

Bols, M .

ACTA CHEMICA SCANDINAVICA, 1998, 52 (04) :461-468

[47] Baker's yeast mediated reduction of optically active diketone [J].

Gao, XL ;

Zhou, G ;

Guan, YK ;

Li, WD ;

Li, YL .

CHINESE CHEMICAL LETTERS, 2001, 12 (04) :291-292

[48] Asymmetric Reduction of Ethyl (S)-4-chloro-3-hydroxy butanoate in an Aqueous-Organic Solvent Biphasic System Using Dried Baker's Yeast [J].

Wu, Xiaodan ;

Han, Xiaoxiang ;

Zhou, Lingxia ;

Li, Ang .

ASIAN JOURNAL OF CHEMISTRY, 2012, 24 (11) :5151-5154

[49] Baker's yeast reduction of PEG-linked acetoacetate [J].

Bonora, GM ;

Drioli, S ;

Forzato, C ;

Nitti, P ;

Pitacco, G .

LETTERS IN ORGANIC CHEMISTRY, 2005, 2 (01) :89-91

[50] The baker's yeast reduction of β-keto esters in the presence of a thioglycoside [J].

不详 .

JOURNAL OF MOLECULAR CATALYSIS B-ENZYMATIC, 2005, 36 (1-6) :71-71

← 1 2 3 4 5 →