Asymmetric reduction of acetophenone with calcium-alginate-entrapped Baker's yeast in organic solvents

被引：45

作者：

Griffin, DR ^{[1
]}

Yang, FX ^{[1
]}

Carta, G ^{[1
]}

Gainer, JL ^{[1
]}

机构：

[1] Univ Virginia, Dept Chem Engn, Charlottesville, VA 22903 USA

来源：

BIOTECHNOLOGY PROGRESS | 1998年 / 14卷 / 04期

关键词：

D O I：

10.1021/bp9800586

中图分类号：

Q81 [生物工程学（生物技术）]; Q93 [微生物学];

学科分类号：

071005 ; 0836 ; 090102 ; 100705 ;

摘要：

Baker's yeast cells entrapped in alginate beads are shown to catalyze reactions in organic solvents when a cofactor regeneration scheme is implemented. This study focused on the reduction of acetophenone to 1-phenylethanol, using baker's yeast as well as a cosubstrate to regenerate the cofactor. The product is a chiral alcohol, and it was desired to maintain a high enantiomeric excess. The effects of parameters such as the addition of a cosubstrate, water content, fermentation time, buffer pH, and bead diameter have been investigated Such a general process may be quite useful when single enantiomers are needed, as well as for the production of other chemicals.

引用

页码：588 / 593

页数：6

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