Visualization of macromolecular structures

被引：0

作者：

O'Donoghue, Sean I. ^{[1
]}

Goodsell, David S. ^{[2
]}

Frangakis, Achilleas S. ^{[3
]}

Jossinet, Fabrice ^{[4
]}

Laskowski, Roman A. ^{[5
]}

Nilges, Michael ^{[6
]}

Saibil, Helen R. ^{[7
]}

Schafferhans, Andrea ^{[1
]}

Wade, Rebecca C. ^{[8
]}

Westhof, Eric ^{[4
]}

Olson, Arthur J. ^{[2
]}

机构：

[1] European Mol Biol Lab, Heidelberg, Germany

[2] Scripps Res Inst, La Jolla, CA 92037 USA

[3] Goethe Univ Frankfurt, Frankfurt, Germany

[4] Univ Strasbourg, CNRS, Inst Biol Mol & Cellulaire, Strasbourg, France

[5] European Bioinformat Inst, Cambridge, England

[6] Inst Pasteur, Paris, France

[7] Univ London Birkbeck Coll, Inst Struct & Mol Biol, London WC1E 7HX, England

[8] HITS, Heidelberg, Germany

来源：

NATURE METHODS | 2010年 / 7卷 / 03期

关键词：

3-DIMENSIONAL STRUCTURES; LIGAND-BINDING; MOLECULAR-DYNAMICS; CRYSTAL-STRUCTURE; FUNCTIONAL SITES; SWISS-MODEL; IMAGE DATA; PROTEIN; DATABASE; DESIGN;

D O I：

10.1038/NMETH.1427

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.

引用

页码：S42 / S55

页数：14

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