Visualization of macromolecular structures

被引：0
作者：
O'Donoghue, Sean I. [1 ]
Goodsell, David S. [2 ]
Frangakis, Achilleas S. [3 ]
Jossinet, Fabrice [4 ]
Laskowski, Roman A. [5 ]
Nilges, Michael [6 ]
Saibil, Helen R. [7 ]
Schafferhans, Andrea [1 ]
Wade, Rebecca C. [8 ]
Westhof, Eric [4 ]
Olson, Arthur J. [2 ]
机构：
[1] European Mol Biol Lab, Heidelberg, Germany
[2] Scripps Res Inst, La Jolla, CA 92037 USA
[3] Goethe Univ Frankfurt, Frankfurt, Germany
[4] Univ Strasbourg, CNRS, Inst Biol Mol & Cellulaire, Strasbourg, France
[5] European Bioinformat Inst, Cambridge, England
[6] Inst Pasteur, Paris, France
[7] Univ London Birkbeck Coll, Inst Struct & Mol Biol, London WC1E 7HX, England
[8] HITS, Heidelberg, Germany
来源：
NATURE METHODS | 2010年 / 7卷 / 03期
关键词：
3-DIMENSIONAL STRUCTURES; LIGAND-BINDING; MOLECULAR-DYNAMICS; CRYSTAL-STRUCTURE; FUNCTIONAL SITES; SWISS-MODEL; IMAGE DATA; PROTEIN; DATABASE; DESIGN;
D O I：
10.1038/NMETH.1427
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Structural biology is rapidly accumulating a wealth of detailed information about protein function, binding sites, RNA, large assemblies and molecular motions. These data are increasingly of interest to a broader community of life scientists, not just structural experts. Visualization is a primary means for accessing and using these data, yet visualization is also a stumbling block that prevents many life scientists from benefiting from three-dimensional structural data. In this review, we focus on key biological questions where visualizing three-dimensional structures can provide insight and describe available methods and tools.
引用
收藏
页码：S42 / S55
页数：14
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