Joint wound healing using polymeric dressing of chitosan/strontium-doped titanium dioxide with high antibacterial activity

被引：18

作者：

Chen, Li ^{[2
]}

Pan, Hong ^{[3
]}

Zhuang, Caifeng ^{[2
]}

Peng, Mengyao ^{[2
]}

Zhang, Li ^{[1
]}

机构：

[1] Rizhao City Hosp Tradit Chinese Med, Dept Emergency, Rizhao 276000, Shandong, Peoples R China

[2] Peoples Hosp RiZhao, Dept Spinal Surg, Rizhao 276800, Shandong, Peoples R China

[3] Peoples Hosp RiZhao, Dept Gen Surg, Rizhao 276800, Shandong, Peoples R China

来源：

MATERIALS LETTERS | 2020年 / 268卷

关键词：

Polymer; Strontium doped titanium dioxide; Biomaterials; Composite materials; Joint wound healing; NANOPARTICLES; REGENERATION; NANOFIBERS; SCAFFOLDS; GREEN;

D O I：

10.1016/j.matlet.2020.127555

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Treatment against bacterial infection is of great significance for joint wound healing in medical nursing care. Thus, it is urgent to develop efficient antibacterial agent with excellent wound healing capability. In this research, a two-step strategy was employed for the development of novel chitosan scaffold reinforced by strontium doped TiO2 nanoparticles (CS/Sr-TiO2). The antibacterial activity of CS/Sr-TiO2 against Escherichia coli, and Staphylococcus aureus were evaluated with the zone of inhibition method. Wound healing properties of CS/Sr-TiO2 were tested in rabbit joint wound, and the Sr-doping is able to achieve a high wound healing rate near 93% after 12 days. Hence the results strongly demonstrate that the CS/Sr-TiO2 nanocomposites may be the promising materials for wound healing application in nursing care with enhanced antibacterial activity and high biocompatibility. (C) 2020 Elsevier B.V. All rights reserved.

引用

页数：3

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