Chronic lung diseases

被引:19
作者
Wu, Wei [1 ]
Kaminski, Naftali [1 ]
机构
[1] Univ Pittsburgh, Sch Med, Dorothy P & Richard P Simmons Ctr Interstitial Lu, Div Pulm Allergy & Crit Care Med, Pittsburgh, PA 15213 USA
关键词
IDIOPATHIC PULMONARY-FIBROSIS; GENE-EXPRESSION; SYSTEMS BIOLOGY; BRONCHOALVEOLAR LAVAGE; MICROARRAY ANALYSIS; MASS-SPECTROMETRY; PROTEOMICS; PATHOGENESIS; SMOKERS; PROTEIN;
D O I
10.1002/wsbm.23
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Chronic lung diseases often have high morbidity and mortality rate and have posed a serious threat to human health. The incidence of many chronic lung diseases such as asthma has been on the rise in the past decade, which causes serious economic burden. Despite many efforts which employed traditional experimental approaches to elucidate the mechanisms of the diseases have been made, little is known about the pathogenesis of complex lung diseases. Systems biology approaches which aim to integrate and analyze information gathered from multiple sources offer a great opportunity to examine complex human diseases from a new angle. Many attempts have been made using high-throughput technologies such as microarrays to study chronic lung diseases; although compared with the full-fledged systems biology approach, research strategies employed in most of these investigations still have much room to improve, promising findings have already emerged from these efforts, which demonstrates the potential of implementing systems biology in pulmonary biomedical research. (C) 2009 John Wiley & Sons, Inc. WIREs Syst Biol Med 2009 1 298-308
引用
收藏
页码:298 / 308
页数:11
相关论文
共 50 条
[41]   Proteomics in detection and monitoring of asthma and smoking-related lung diseases [J].
Lin, Jiun-Lih ;
Bonnichsen, Mark H. ;
Nogeh, Emily U. ;
Raftery, Mark J. ;
Thomas, Paul S. .
EXPERT REVIEW OF PROTEOMICS, 2010, 7 (03) :361-372
[42]   Venous Thromboembolic Disease in Chronic Inflammatory Lung Diseases: Knowns and Unknowns [J].
Keramidas, George ;
Gourgoulianis, Konstantinos I. ;
Kotsiou, Ourania S. .
JOURNAL OF CLINICAL MEDICINE, 2021, 10 (10)
[43]   Prevalence and prognosis of chronic fibrosing interstitial lung diseases with a progressive phenotype [J].
Takei, Reoto ;
Brown, Kevin K. ;
Yamano, Yasuhiko ;
Kataoka, Kensuke ;
Yokoyama, Toshiki ;
Matsuda, Toshiaki ;
Kimura, Tomoki ;
Suzuki, Atsushi ;
Furukawa, Taiki ;
Fukuoka, Junya ;
Johkoh, Takeshi ;
Goto, Yoshihito ;
Kondoh, Yasuhiro .
RESPIROLOGY, 2022, 27 (05) :333-340
[44]   Advances and applications of monoolein as a novel nanomaterial in mitigating chronic lung diseases [J].
Chan, Yinghan ;
Singh, Sachin Kumar ;
Gulati, Monica ;
Wadhwa, Sheetu ;
Prasher, Parteek ;
Kumar, Deepak ;
Kumar, Avvaru Praveen ;
Gupta, Gaurav ;
Kuppusamy, Gowthamarajan ;
Haghi, Mehra ;
Oliver, Brian Gregory George ;
Adams, Jon ;
Chellappan, Dinesh Kumar ;
Dua, Kamal .
JOURNAL OF DRUG DELIVERY SCIENCE AND TECHNOLOGY, 2022, 74
[45]   Pulmonary Hypertension in Chronic Obstructive Pulmonary Disease and Interstitial Lung Diseases [J].
Weitzenblum, Emmanuel ;
Chaouat, Ari ;
Canuet, Matthieu ;
Kessler, Romain .
SEMINARS IN RESPIRATORY AND CRITICAL CARE MEDICINE, 2009, 30 (04) :458-470
[46]   The utility of bronchoalveolar lavage in the evaluation of interstitial lung diseases: A clinicopathological perspective [J].
Gharsalli, Houda ;
Mlika, Mouna ;
Sahnoun, Imen ;
Maalej, Sonia ;
El Gharbi, Leila Douik ;
El Mezni, Faouzi .
SEMINARS IN DIAGNOSTIC PATHOLOGY, 2018, 35 (05) :280-287
[47]   Comparison of the upper and lower airway microbiota in children with chronic lung diseases [J].
Ahmed, Bushra ;
Cox, Michael J. ;
Cuthbertson, Leah ;
James, Phillip L. ;
Cookson, William O. C. ;
Davies, Jane C. ;
Moffatt, Miriam F. ;
Bush, Andrew .
PLOS ONE, 2018, 13 (08)
[48]   Nintedanib in chronic fibrosing interstitial lung diseases. A case series [J].
Sevila, Raquel Garcia ;
Jimenez, Juan Jose Arenas ;
Casasempere, Paloma Vela ;
Perez, Ester Nofuentes ;
Garcia-Manso, Ignacio Gaya .
HELIYON, 2024, 10 (07)
[49]   Adenovirus Species C Is Associated With Chronic Suppurative Lung Diseases in Children [J].
Wurzel, Danielle F. ;
Mackay, Ian M. ;
Marchant, Julie M. ;
Wang, Claire Y. T. ;
Yerkovich, Stephanie T. ;
Upham, John W. ;
Smith-Vaughan, Heidi C. ;
Petsky, Helen L. ;
Chang, Anne B. .
CLINICAL INFECTIOUS DISEASES, 2014, 59 (01) :34-40
[50]   'WNT-er is coming': WNT signalling in chronic lung diseases [J].
Baarsma, H. A. ;
Konigshoff, M. .
THORAX, 2017, 72 (08) :746-759