Human T Lymphotropic Virus Type 1 (HTLV-1): Molecular Biology and Oncogenesis

被引：86

作者：

Kannian, Priya ^{[1
,2
]}

Green, Patrick L. ^{[1
,2
,3
,4
,5
]}

机构：

[1] Ohio State Univ, Ctr Retrovirus Res, Columbus, OH 43210 USA

[2] Ohio State Univ, Dept Vet Biosci, Columbus, OH 43210 USA

[3] Ohio State Univ, Dept Mol Virol Immunol & Med Genet, Columbus, OH 43210 USA

[4] Ohio State Univ, Ctr Comprehens Canc, Columbus, OH 43210 USA

[5] Ohio State Univ, Solove Res Inst, Columbus, OH 43210 USA

来源：

VIRUSES-BASEL | 2010年 / 2卷 / 09期

关键词：

HTLV-1; leukemogenesis; cellular transformation; Tax; HBZ; CELL LEUKEMIA-VIRUS; NF-KAPPA-B; I TAX PROTEIN; LEUCINE-ZIPPER-FACTOR; BZIP FACTOR HBZ; SERUM RESPONSE FACTOR; LONG TERMINAL REPEAT; OPEN READING FRAMES; NUCLEAR-FACTOR; GENE-EXPRESSION;

D O I：

10.3390/v2092037

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Human T lymphotropic viruses (HTLVs) are complex deltaretroviruses that do not contain a proto-oncogene in their genome, yet are capable of transforming primary T lymphocytes both in vitro and in vivo. There are four known strains of HTLV including HTLV type 1 (HTLV-1), HTLV-2, HTLV-3 and HTLV-4. HTLV-1 is primarily associated with adult T cell leukemia (ATL) and HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP). HTLV-2 is rarely pathogenic and is sporadically associated with neurological disorders. There have been no diseases associated with HTLV-3 or HTLV-4 to date. Due to the difference in the disease manifestation between HTLV-1 and HTLV-2, a clear understanding of their individual pathobiologies and the role of various viral proteins in transformation should provide insights into better prognosis and prevention strategies. In this review, we aim to summarize the data accumulated so far in the transformation and pathogenesis of HTLV-1, focusing on the viral Tax and HBZ and citing appropriate comparisons to HTLV-2.

引用

页码：2037 / 2077

页数：41

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