Functionalized cationic (η6-arene)ruthenium(II) complexes for site-specific and covalent anchoring to papain from papaya latex.: Synthesis, X-ray structures and reactivity studies

被引：27

作者：

Haquette, Pierre ^{[1
]}

Talbi, Barisa ^{[1
]}

Canaguier, Sigolene

Dagorne, Samuel ^{[2
]}

Fosse, Celine ^{[3
]}

Martel, Annie ^{[1
]}

Jaouen, Gerard ^{[1
]}

Salmain, Michele ^{[1
]}

机构：

[1] Ecole Natl Super Chim Paris, CNRS, UMR 7576, Lab Chim & Biochim Complexes Mol, F-75231 Paris 05, France

[2] CNRS, Inst Le Bel, Inst Chim, UMR 7177,Lab DECOMET, F-67000 Strasbourg, France

[3] Ecole Natl Super Chim Paris, CNRS, UMR 7573, Lab Synth Select Organ & Prod Nat Equipe Spectome, F-75231 Paris 05, France

来源：

TETRAHEDRON LETTERS | 2008年 / 49卷 / 31期

关键词：

ruthenium complexes; papain; S-alkylation;

D O I：

10.1016/j.tetlet.2008.05.043

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The cationic (eta(6)-arene)ruthenium complexes 6-9 containing a chloroacetamide or a maleimide functional group on the arene ligand were synthesized and successfully used to introduce ruthenium(II) species to the active site of the cysteine endoprotemase papain in a site-directed and covalent fashion as shown by enzymatic and ESI-MS studies. (C) 2008 Elsevier Ltd. All rights reserved.

引用

页码：4670 / 4673

页数：4

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