Headspace solid phase micro extraction gas chromatographic determination of fenthion in human serum

被引:10
作者
Kasiotis, Konstantinos M. [1 ]
Souki, Helen [2 ]
Tsakirakis, Angelos N. [1 ]
Carageorgiou, Haris [2 ]
Theotokatos, Spiridon A. [3 ]
Haroutounian, Serkos A. [4 ]
Machera, Kyriaki [1 ]
机构
[1] Benaki Phytopathol Inst, Pesticide Toxicol Lab, Athens 14561, Greece
[2] Univ Athens, Dept Pharmacol, Sch Med, Athens 11527, Greece
[3] Agroind Robola Growers Cooperat Kefalllinia, Omala 28100, Kefallinia, Greece
[4] Agr Univ Athens, Chem Lab, Athens 11855, Greece
来源
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES | 2008年 / 9卷 / 05期
关键词
insecticide residue; olive; fenthion; headspace; SPME; GC/MS; metabolites;
D O I
10.3390/ijms9050906
中图分类号
Q5 [生物化学]; Q7 [分子生物学];
学科分类号
071010 ; 081704 ;
摘要
A simple and effective analytical procedure was developed for the determination of fenthion residues in human serum samples. The sample treatment was performed using the headspace solid-phase micro extraction with polyacrylate fiber, which has the advantage to require low amount of serum (1 mL) without tedious pre-treatment. The quantification of fenthion was carried out by gas chromatography-mass spectrometry and the recoveries ranged from 79 to 104% at two spiking levels for 6 replicates. Detection and quantification limits were calculated as 1.51 and 4.54 ng/mL of serum respectively. Two fenthion metabolites - fenoxon and fenthion-sulfoxide - were also identified.
引用
收藏
页码:906 / 913
页数:8
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