Astrocyte activation and reactive gliosis-A new target in stroke?

被引：169

作者：

Pekny, Milos ^{[1
,3
,4
]}

Wilhelmsson, Ulrika ^{[1
]}

Tatlisumak, Turgut ^{[1
,2
]}

Pekna, Marcela ^{[1
,3
,4
]}

机构：

[1] Univ Gothenburg, Sahlgrenska Acad, Inst Neurosci & Physiol, Ctr Brain Repair,Dept Clin Neurosci, Box 440, S-40530 Gothenburg, Sweden

[2] Sahlgrens Univ Hosp, Dept Neurol, Gothenburg, Sweden

[3] Florey Inst Neurosci & Mental Hlth, Parkville, Vic, Australia

[4] Univ Newcastle, Newcastle, NSW, Australia

来源：

NEUROSCIENCE LETTERS | 2019年 / 689卷

基金：

瑞典研究理事会; 英国医学研究理事会;

关键词：

Astrocytes; Reactive gliosis; Intermediate filaments (Nanofilaments); GFAP; Vimentin; Nestin; Stroke; Brain ischemia; Perinatal asphyxia; The complement system; C3; C3a; Neural plasticity; Brain repair; FIBRILLARY ACIDIC PROTEIN; COMPLEMENT PEPTIDE C3A; PROMOTES FUNCTIONAL RECOVERY; REGULATORY VOLUME DECREASE; FOCAL CEREBRAL-ISCHEMIA; INTERMEDIATE-FILAMENTS; MICE DEFICIENT; CHONDROITINASE ABC; NEURAL PLASTICITY; CELL-VOLUME;

D O I：

10.1016/j.neulet.2018.07.021

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Stroke is an acute insult to the central nervous system (CNS) that triggers a sequence of responses in the acute, subacute as well as later stages, with prominent involvement of astrocytes. Astrocyte activation and reactive gliosis in the acute stage of stroke limit the tissue damage and contribute to the restoration of homeostasis. Astrocytes also control many aspects of neural plasticity that is the basis for functional recovery. Here, we discuss the concept of intermediate filaments (nanofilaments) and the complement system as two handles on the astrocyte responses to injury that both present attractive opportunities for novel treatment strategies modulating astrocyte functions and reactive gliosis.

引用

页码：45 / 55

页数：11

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