Immune cell signaling defects in lupus: activation, anergy and death

被引：103
作者：
Tsokos, GC
Liossis, SNC
机构：
[1] Uniformed Serv Univ Hlth Sci, Dept Med, Div Rheumatol & Immunol, Bethesda, MD 20814 USA
[2] Walter Reed Army Med Ctr, Dept Clin Physiol, Washington, DC 20307 USA
来源：
IMMUNOLOGY TODAY | 1999年 / 20卷 / 03期
关键词：
D O I：
10.1016/S0167-5699(98)01395-4
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Recent studies have identified novel aberrations in antigen receptor-mediated signaling events in lymphocytes from patients with systemic lupus erythematosus. Here, we propose that in lupus lymphocytes, the receptor-mediated increase in protein tyrosine phosphorylation and cytoplasmic free Ca2+ responses, along with T-cell receptor zeta chain deficiency, might explain the previously described diverse and conflicting immunoregulatory defects in human lupus.
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收藏
页码：119 / 124
页数：6
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