Carboxymethylated chitosan-stabilized copper nanoparticles: a promise to contribute a potent antifungal and antibacterial agent

被引：16

作者：

Tantubay, Sangeeta ^{[1
]}

Mukhopadhyay, Sourav K. ^{[2
]}

Kalita, Himani ^{[1
]}

Konar, Suraj ^{[1
]}

Dey, Satyahari ^{[2
]}

Pathak, Amita ^{[1
]}

Pramanik, Panchanan ^{[1
]}

机构：

[1] Indian Inst Technol Kharagpur, Dept Chem, Kharagpur 721302, W Bengal, India

[2] Indian Inst Technol Kharagpur, Dept Biotechnol, Kharagpur 721302, W Bengal, India

来源：

JOURNAL OF NANOPARTICLE RESEARCH | 2015年 / 17卷 / 06期

关键词：

Copper nanoparticles (Cu-NPs); Carboxymethylated chitosan (CMC); Antifungal; Antibacterial; C; tropicalis; E; coli; Toxicity study; ANTIMICROBIAL ACTIVITY; SILVER NANOPARTICLES; GOLD NANOPARTICLES; STARCH; FILMS; SIZE;

D O I：

10.1007/s11051-015-3047-9

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Carboxymethylated chitosan (CMC)-stabilized copper nanoparticles (Cu-NPs) have been synthesized via chemical reduction of copper(II)-CMC complex in aqueous medium by hydrazine under microwave irradiation in ambient atmosphere. Structural morphology, phase, and chemical compositions of CMC-stabilized Cu-NPs (CMC-Cu-NPs) have been analyzed through high-resolution transmission electron microscopy, field emission scanning electron microscopy, X-ray diffraction, and X-ray photoelectron spectroscopy. Antifungal and antibacterial activities of CMC-Cu-NPs have been evaluated against Candida tropicalis and Escherichia coli through agar well diffusion method, broth microdilution assay, live-dead assay, and microscopic observation. Antimicrobial activity of spherical CMC-Cu-NPs (similar to 4-15 nm of diameters) has been observed to be significant for both C. tropicalis and E. coli. The cytotoxicity study indicates that CMC-Cu-NPs have no significant toxic effect against normal cell line, L929.

引用

页数：18

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