Aminoacyl-tRNA synthetases: potential markers of genetic code development

被引：119

作者：

de Pouplana, LR

Schimmel, P

机构：

[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA

[2] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA

[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 10期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1016/S0968-0004(01)01932-6

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aminoacylation of tRNAs, catalyzed by 20 aminoacyl-tRNA synthetases, is responsible for establishing the genetic code. The enzymes are divided into two classes on the basis of the architectures of their active sites. Members of the two classes also differ in that they bind opposite sides of the tRNA acceptor stem. Importantly, specific pairs of synthetases - one from each class - can be docked simultaneously onto the acceptor stem. This article relates these specific pairings to the organization of the table of codons that defines the universal genetic code.

引用

页码：591 / 596

页数：6

共 50 条

[21] Mammalian aminoacyl-tRNA synthetases
Yang, DCH
CURRENT TOPICS IN CELLULAR REGULATION, VOL 34, 1996, 34 : 101 - 136
[22] The evolution of Class II Aminoacyl-tRNA synthetases and the first code
Smith, Temple F.
Hartman, Hyman
FEBS LETTERS, 2015, 589 (23) : 3499 - 3507
[23] On the origin of the genetic code: signatures of its primordial complementarity in tRNAs and aminoacyl-tRNA synthetases
Rodin, S. N.
Rodin, A. S.
HEREDITY, 2008, 100 (04) : 341 - 355
[24] Aminoacyl-tRNA Synthetases and tRNAs for an Expanded Genetic Code: What Makes them Orthogonal?
Melnikov, Sergey V.
Soll, Dieter
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2019, 20 (08)
[25] On the origin of the genetic code: signatures of its primordial complementarity in tRNAs and aminoacyl-tRNA synthetases
S N Rodin
A S Rodin
Heredity, 2008, 100 : 341 - 355
[26] Croatian school on tRNA and aminoacyl-tRNA synthetases
Weygand-Durasevic, I
CROATICA CHEMICA ACTA, 2005, 78 (03) : 319 - 324
[27] A tRNA- and Anticodon-Centric View of the Evolution of Aminoacyl-tRNA Synthetases, tRNAomes, and the Genetic Code
Kim, Yunsoo
Opron, Kristopher
Burton, Zachary F.
LIFE-BASEL, 2019, 9 (02):
[28] Aminoacyl-tRNA synthetases and aminoacylation of tRNA in the nucleus
Mucha, P
ACTA BIOCHIMICA POLONICA, 2002, 49 (01) : 1 - 10
[29] Footprints of aminoacyl-tRNA synthetases are everywhere
Schimmel, P
De Pouplana, LR
TRENDS IN BIOCHEMICAL SCIENCES, 2000, 25 (05) : 207 - 209
[30] Noncanonical functions of aminoacyl-tRNA synthetases
E. V. Smirnova
V. A. Lakunina
I. Tarassov
I. A. Krasheninnikov
P. A. Kamenski
Biochemistry (Moscow), 2012, 77 : 15 - 25

← 1 2 3 4 5 →