Aminoacyl-tRNA synthetases: potential markers of genetic code development

被引：120
作者：
de Pouplana, LR
Schimmel, P
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
[2] Scripps Res Inst, Dept Biol Mol, La Jolla, CA 92037 USA
[3] Scripps Res Inst, Dept Chem, La Jolla, CA 92037 USA
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 2001年 / 26卷 / 10期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0968-0004(01)01932-6
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Aminoacylation of tRNAs, catalyzed by 20 aminoacyl-tRNA synthetases, is responsible for establishing the genetic code. The enzymes are divided into two classes on the basis of the architectures of their active sites. Members of the two classes also differ in that they bind opposite sides of the tRNA acceptor stem. Importantly, specific pairs of synthetases - one from each class - can be docked simultaneously onto the acceptor stem. This article relates these specific pairings to the organization of the table of codons that defines the universal genetic code.
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页码：591 / 596
页数：6
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