The association between runt-related transcription factor 3 gene promoter methylation and gastric cancer: A meta-analysis

被引：5
|
作者：
Liu, Xu [1 ]
Wang, Lina [2 ]
Guo, Yongtie [1 ]
机构：
[1] Tianjin Univ TCM, Teaching Hosp 1, Dept Clin Lab, Tianjin 300193, Peoples R China
[2] Second Peoples Hosp, Dept Clin Lab, Tianjin 300192, Peoples R China
来源：
JOURNAL OF CANCER RESEARCH AND THERAPEUTICS | 2016年 / 12卷 / 05期
关键词：
Gastric cancer; meta-analysis; methylation; runt-related transcription factor 3 gene; EXPRESSION; HYPERMETHYLATION;
D O I：
10.4103/0973-1482.191630
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Objective: To systematically evaluate the relationship of the methylation of the human-runt-related transcription factor 3 (RUNX3) promoter region and gastric cancer risk through meta-analysis. Materials and Methods: The studies published in PubMed, EMBASE, Ovid, and CNKI were retrieved. The association between RUNX3 gene promoter methylation and gastric cancer was analyzed using Stata 11.0 (; Stata Corporation, College Station, TX, USA) and Review Man 5.0 software (). Results: Seventeen studies are included in the analysis. Meta-analysis reveals that the odds ratio of the methylation of the RUNX3 promoter region in gastric was 7.32 (95% confidence interval: 5.12u10.47), which was significant higher than the normal gastric tissues (P < 0.05). Conclusions: The RUNX3 gene promoter methylation rate was much higher in tumor tissue than that in normal gastric tissue in patient with gastric cancer, which indicates a close association between gastric cancer and RUNX3 gene promoter methylation.
引用
收藏
页码：50 / 53
页数：4
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