N,N-dicarboxymethyl chitosan as delivery agent for bone morphogenetic protein in the repair of articular cartilage

被引：74

作者：

Mattioli-Belmonte, M

Gigante, A

Muzzarelli, RAA

Politano, R

De Benedittis, A

Specchia, N

Buffa, A

Biagini, G

Greco, F

机构：

[1] Univ Ancona, Fac Med, Inst Normal Human Morphol, I-60020 Ancona, Italy

[2] Univ Ancona, Ctr Innovat Biomat, Ancona, Italy

[3] Univ Ancona, Inst Biochem, Ancona, Italy

[4] Univ Ancona, Orthoped Clin, Ancona, Italy

[5] Univ Bologna, Dept Gen Med, Bologna, Italy

来源：

MEDICAL & BIOLOGICAL ENGINEERING & COMPUTING | 1999年 / 37卷 / 01期

关键词：

chitosan; bone morphogenetic protein; articular cartilage lesions; drug carrier;

D O I：

10.1007/BF02513279

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

Bone morphogenetic protein (BMP), associated with N,N-dicarboxymethyl chitosan, is used to induce or facilitate the repair of articular cartilage lesions. This association is intended for the synergistic potentiation of the respective biological effects. Data show that BMP-7 enhances the in vivo proliferation of cells with chondrocytes phenotype in the articular environment, leading to partial healing of the articular surface of the lesions. N,N-dicarboxymethyl chitosan is found to be useful as a molecular carrier or drug delivery agent.

引用

页码：130 / 134

页数：5

共 39 条

[1] Modulation of cranial bone healing with a heparin-like dextran derivative [J].