Solvent-controlled highly regio-selective thieno [2,3-b]indole formation under metal-free conditions

被引：67

作者：

Ni, Penghui ^{[1
]}

Li, Bin ^{[1
]}

Huang, Huawen ^{[1
]}

Xiao, Fuhong ^{[1
]}

Deng, Guo-Jun ^{[1
]}

机构：

[1] Xiangtan Univ, Key Lab Green Organ Synth & Applicat Hunan Prov, Key Lab Environm Friendly Chem & Applicat, Minist Educ,Coll Chem, Xiangtan 411105, Peoples R China

来源：

GREEN CHEMISTRY | 2017年 / 19卷 / 23期

基金：

中国国家自然科学基金;

关键词：

TRISULFUR RADICAL-ANION; MULTICOMPONENT REACTIONS; ELEMENTAL SULFUR; STREPTOMYCETE STRAIN; DERIVATIVES; FACILE; ROUTE; ANNULATION; SCAFFOLDS; THIOPHENE;

D O I：

10.1039/c7gc02818k

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient three-component thieno[2,3-b] indole formation method was developed under metal-free conditions. The cascade cyclization was enabled by acid-promoted annulation of indoles, ketones and sulfur powder, which enabled modular synthesis of 2-substituted and 3-substituted thieno[2,3-b] indoles with excellent regioselectivity and broad functional group tolerance. DMF solvent played an important role in the regioselectivity control.

引用

页码：5553 / 5558

页数：6

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