Prevalence of HIV Drug Resistance Before and 1 Year After Treatment Initiation in 4 Sites in the Malawi Antiretroviral Treatment Program

被引：16

作者：

Wadonda-Kabondo, Nellie ^{[1
]}

Bennett, Diane ^{[2
]}

van Oosterhout, Joep J. ^{[3
]}

Moyo, Kundai

Hosseinipour, Mina ^{[4
]}

DeVos, Josh ^{[5
]}

Zhou, Zhiyong ^{[5
]}

Aberle-Grasse, John ^{[2
]}

Warne, Thomas R. ^{[6
,7
]}

Mtika, Clement ^{[8
]}

Chilima, Ben

Banda, Richard ^{[9
]}

Pasulani, Olesi

Porter, Carol

Phiri, Sam

Jahn, Andreas ^{[10
]}

Kamwendo, Debbie ^{[4
]}

Jordan, Michael R. ^{[11
,12
]}

Kabuluzi, Storn

Chimbwandira, Frank

Kagoli, Mathew

Matatiyo, Blackson

Demby, Austin ^{[6
,7
]}

Yang, Chunfu ^{[5
]}

机构：

[1] Minist Hlth, Community Hlth Serv Unit, Dept Prevent Hlth, Lilongwe, Malawi

[2] Ctr Dis Control & Prevent, Strateg Informat & Epidemiol Branch, Div Global HIV AIDS, Atlanta, GA USA

[3] Univ Malawi, Coll Med, Blantyre, Malawi

[4] UNC Project, Lilongwe, Malawi

[5] Ctr Dis Control & Prevent, Int Lab Branch, Div Global HIV AIDS, Atlanta, GA USA

[6] Ctr Dis Control, Lilongwe, Malawi

[7] Prevent Global AIDS Program, Lilongwe, Malawi

[8] Mzuzu Cent Hosp, Minist Hlth, Lilongwe, Malawi

[9] World Hlth Org, Dept Inter Country Support, Harare, Zimbabwe

[10] Minist Hlth, HIV AIDS Dept, Lilongwe, Malawi

[11] World Hlth Org, Dept HIV, Geneva, Switzerland

[12] Tufts Univ, Sch Med, Dept Geog Med & Infect Dis, Boston, MA 02111 USA

来源：

CLINICAL INFECTIOUS DISEASES | 2012年 / 54卷

基金：

美国国家卫生研究院; 比尔及梅琳达.盖茨基金会;

关键词：

FIXED-DOSE COMBINATION; WORLD-HEALTH-ORGANIZATION; REVERSE-TRANSCRIPTASE; TREATMENT FAILURE; THERAPY; MUTATIONS; ADULTS; CHILDREN; CRITERIA; REGIMEN;

D O I：

10.1093/cid/cir987

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Since 2004, the Malawi antiretroviral treatment (ART) program has provided a public health-focused system based on World Health Organization clinical staging, standardized first-line ART regimens, limited laboratory monitoring, and no patient-level monitoring of human immunodeficiency virus drug resistance (HIVDR). The Malawi Ministry of Health conducts periodic evaluations of HIVDR development in prospective cohorts at sentinel clinics. We evaluated viral load suppression, HIVDR, and factors associated with HIVDR in 4 ART sites at 12-15 months after ART initiation. More than 70% of patients initiating ART had viral suppression at 12 months. HIVDR prevalence (6.1%) after 12 months of ART was low and largely associated with baseline HIVDR. Better follow-up, removal of barriers to on-time drug pickups, and adherence education for patients 16-24 years of age may further prevent HIVDR.

引用

页码：S362 / S368

页数：7

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