Overview and developments in noninvasive diagnosis of nonalcoholic fatty liver disease

被引:55
作者
Barsic, Neven [1 ]
Lerotic, Ivan [1 ]
Smircic-Duvnjak, Lea [2 ]
Tomasic, Vedran [1 ]
Duvnjak, Marko [1 ]
机构
[1] Sestre Milosrdnice Univ Hosp Ctr, Div Gastroenterol & Hepatol, Dept Med, Zagreb 10000, Croatia
[2] Vuk Vrhovac Univ Clin Diabet Endocrinol & Metab D, Zagreb 10000, Croatia
关键词
Non-alcoholic fatty liver disease; Non-alcoholic steatohepatitis; Liver fibrosis; Liver biopsy; Biomarkers; Transient elastography; Cytokeratin-18; Oxidative stress; Insulin resistance; Hyaluronic acid; C-REACTIVE PROTEIN; INSULIN-RESISTANCE; BIOCHEMICAL MARKERS; HEPATIC-FIBROSIS; TRANSIENT ELASTOGRAPHY; STIFFNESS MEASUREMENT; PLASMA ADIPONECTIN; SCORING SYSTEM; TNF-ALPHA; STEATOHEPATITIS;
D O I
10.3748/wjg.v18.i30.3945
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
High prevalence of non-alcoholic fatty liver disease (NAFLD) and very diverse outcomes that are related to disease form and severity at presentation have made the search for noninvasive diagnostic tools in NAFLD one of the areas with most intense development in hepatology today. Various methods have been investigated in the recent years, including imaging methods like ultrasound and magnetic resonance imaging, different forms of liver stiffness measurement, various biomarkers of necroinflammatory processes (acute phase reactants, cytokines, markers of apoptosis), hyaluronic acid and other biomarkers of liver fibrosis. Multicomponent tests, scoring systems and diagnostic panels were also developed with the purposes of differentiating non-alcoholic steatohepatitis from simple steatosis or discriminating between various fibrosis stages. In all of the cases, performance of noninvasive methods was compared with liver biopsy, which is still considered to be a gold standard in diagnosis, but is by itself far from a perfect comparative measure. We present here the overview of the published data on various noninvasive diagnostic tools, some of which appear to be very promising, and we address as well some of still unresolved issues in this interesting field. (C) 2012 Baishideng. All rights reserved.
引用
收藏
页码:3945 / 3954
页数:10
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