Self-Reporting Degradable Fluorescent Grafted Copolymer Micelles Derived from Biorenewable Resources

被引:30
作者
Noel, Amandine
Borguet, Yannick P.
Wooley, Karen L. [1 ]
机构
[1] Texas A&M Univ, Dept Chem, College Stn, TX 77842 USA
来源
ACS MACRO LETTERS | 2015年 / 4卷 / 06期
基金
美国国家科学基金会; 美国国家卫生研究院;
关键词
TARGETED DRUG-DELIVERY; POLY(FERULIC ACID-CO-TYROSINE); POLYMERIC NANOPARTICLES; BIOMEDICAL APPLICATIONS; NANOMEDICINE; CHALLENGES; PARTICLES; INFECTION; CMC;
D O I
10.1021/acsmacrolett.5b00227
中图分类号
O63 [高分子化学(高聚物)];
学科分类号
070305 ; 080501 ; 081704 ;
摘要
A series of hydrolytically degradable fluorescent poly(ferulic acid-co-tyrosine)-g-mPEG graft copolymers were synthesized and shown to undergo self-assembly in aqueous media to yield fluorescent micelles. The polymers and their micellar assemblies exhibited greater fluorescence emission intensity than did their small molecular building blocks, which provides a self-reporting character that has potential for monitoring the polymer integrity and also for performing in theranostics applications. The amphiphilic graft-copolymers were synthesized by Cu-assisted azide-alkyne "click" addition of azido-functionalized mPEG polymers onto fluorescent degradable hydrophobic copolymers displaying randomly distributed alkyne side-chain groups along their biorenewably derived poly(ferulic acid-co-tyrosine) backbones. The morphologies and photophysical properties of the supramolecular assemblies generated in aqueous solutions were evaluated by DLS, TEM, AFM, and steady-state optical spectroscopies. The 15-30 nm sized micelles behaved as broad-band emitters in the 350-600 nm range, which highlights their potential as self-reporting nanomaterials for in vitro studies.
引用
收藏
页码:645 / 650
页数:6
相关论文
共 36 条
[1]   Diffusion ordered spectroscopy (DOSY) as a powerful tool for amphiphilic block copolymer characterization and for critical micelle concentration (CMC) determination [J].
Bakkour, Youssef ;
Darcos, Vincent ;
Li, Suming ;
Coudane, Jean .
POLYMER CHEMISTRY, 2012, 3 (08) :2006-2010
[2]   Multi-functional self-fluorescent unimolecular micelles for tumor-targeted drug delivery and bioimaging [J].
Chen, Guojun ;
Wang, Liwei ;
Cordie, Travis ;
Vokoun, Corinne ;
Eliceiri, Kevin W. ;
Gong, Shaoqin .
BIOMATERIALS, 2015, 47 :41-50
[3]   Non-spherical particles for targeted drug delivery [J].
Chen, Jinrong ;
Clay, Nicholas E. ;
Park, No-hyung ;
Kong, Hyunjoon .
CHEMICAL ENGINEERING SCIENCE, 2015, 125 :20-24
[4]   Multifunctional magnetic-fluorescent nanocomposites for biomedical applications [J].
Corr, Serena A. ;
Rakovich, Yury P. ;
Gun'ko, Yurii K. .
NANOSCALE RESEARCH LETTERS, 2008, 3 (03) :87-104
[5]   Design of polymeric nanoparticles for biomedical delivery applications [J].
Elsabahy, Mahmoud ;
Wooley, Karen L. .
CHEMICAL SOCIETY REVIEWS, 2012, 41 (07) :2545-2561
[6]   Synthesis and Fluorescence Properties of N-Substituted 1-Cyanobenz[f]isoindole Chitosan Polymers and Nanoparticles for Live Cell Imaging [J].
Gonil, Pattarapond ;
Sajomsang, Warayuth ;
Ruktanonchai, Uracha Rungsardthong ;
Ubol, Preeyawis Na ;
Treetong, Alongkot ;
Opanasopit, Praneet ;
Puttipipatkhachorn, Satit .
BIOMACROMOLECULES, 2014, 15 (08) :2879-2888
[7]   Ultrabright Fluorescent Polymeric Nanoparticles Made from a New Family of BODIPY Monomers [J].
Grazon, Chloe ;
Rieger, Jutta ;
Meallet-Renault, Rachel ;
Charleux, Bernadette ;
Clavier, Gilles .
MACROMOLECULES, 2013, 46 (13) :5167-5176
[8]   Fluorescence Imaging Enabled Biodegradable Photostable Polymeric Micelles [J].
Gyawali, Dipendra ;
Zhou, Shengyuan ;
Tran, Richard T. ;
Zhang, Yi ;
Liu, Chao ;
Bai, Xiaochun ;
Yang, Jian .
ADVANCED HEALTHCARE MATERIALS, 2014, 3 (02) :182-186
[9]   Encapsulating Light-Emitting Polymers in Block Copolymer Micelles [J].
Jung, Yeongri ;
Hickey, Robert J. ;
Park, So-Jung .
LANGMUIR, 2010, 26 (10) :7540-7543
[10]   DAPI - A DNA-SPECIFIC FLUORESCENT-PROBE [J].
KAPUSCINSKI, J .
BIOTECHNIC & HISTOCHEMISTRY, 1995, 70 (05) :220-233