Actin Filaments as Tension Sensors

被引：130

作者：

Galkin, Vitold E. ^{[1
]}

Orlova, Albina ^{[1
]}

Egelman, Edward H. ^{[1
]}

机构：

[1] Univ Virginia, Dept Biochem & Mol Genet, Charlottesville, VA 22908 USA

来源：

CURRENT BIOLOGY | 2012年 / 22卷 / 03期

关键词：

F-ACTIN; SLIDING MOVEMENT; CROSS-LINKING; YEAST ACTIN; COFILIN; BINDING; DYNAMICS; COOPERATIVITY; INHIBITION; MUTATIONS;

D O I：

10.1016/j.cub.2011.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The field of mechanobiology has witnessed an explosive growth over the past several years as interest has greatly increased in understanding how mechanical forces are transduced by cells and how cells migrate, adhere and generate traction. Actin, a highly abundant and anomalously conserved protein, plays a large role in forming the dynamic cytoskeleton that is so essential for cell form, motility and mechanosensitivity. While the actin filament (F-actin) has been viewed as dynamic in terms of polymerization and depolymerization, new results suggest that F-actin itself may function as a highly dynamic tension sensor. This property may help explain the unusual conservation of actin's sequence, as well as shed further light on actin's essential role in structures from sarcomeres to stress fibers.

引用

页码：R96 / R101

页数：6

共 50 条

[11] Direct visualization of secondary structures of F-actin by electron cryomicroscopy [J].

Fujii, Takashi ;

Iwane, Atsuko H. ;

Yanagida, Toshio ;

Namba, Keiichi .

NATURE, 2010, 467 (7316) :724-U117

[12] Actin depolymerizing factor stabilizes an existing state of F-actin and can change the tilt of F-actin subunits [J].

Galkin, VE ;

Orlova, A ;

Lukoyanova, N ;

Wriggers, W ;

Egelman, EH .

JOURNAL OF CELL BIOLOGY, 2001, 153 (01) :75-86

[13] Remodeling of actin filaments by ADF/cofilin proteins [J].

Galkin, Vitold E. ;

Orlova, Albina ;

Kudryashov, Dmitri S. ;

Solodukhin, Alexander ;

Reisler, Emil ;

Schroeder, Gunnar F. ;

Egelman, Edward H. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2011, 108 (51) :20568-20572

[14] Structural polymorphism in F-actin [J].

Galkin, Vitold E. ;

Orlova, Albina ;

Schroeder, Gunnar F. ;

Egelman, Edward H. .

NATURE STRUCTURAL & MOLECULAR BIOLOGY, 2010, 17 (11) :1318-U169

[15] Structural Polymorphism of the ParM Filament and Dynamic Instability [J].

Galkin, Vitold E. ;

Orlova, Albina ;

Rivera, Chris ;

Mullins, R. Dyche ;

Egelman, Edward H. .

STRUCTURE, 2009, 17 (09) :1253-1264

[16] Force amplification response of actin filaments under confined compression [J].

Greene, George W. ;

Anderson, Travers H. ;

Zeng, Hongbo ;

Zappone, Bruno ;

Israelachvili, Jacob N. .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (02) :445-449

[17] AXIAL PERIOD OF ACTIN FILAMENTS [J].

HANSON, J .

NATURE, 1967, 213 (5074) :353-&

[18] Actin filaments function as a tension sensor by tension-dependent binding of cofilin to the filament [J].

Hayakawa, Kimihide ;

Tatsumi, Hitoshi ;

Sokabe, Masahiro .

JOURNAL OF CELL BIOLOGY, 2011, 195 (05) :721-727

[19] X-RAY-DIFFRACTION MEASUREMENTS OF THE EXTENSIBILITY OF ACTIN AND MYOSIN-FILAMENTS IN CONTRACTING MUSCLE [J].

HUXLEY, HE ;

STEWART, A ;

SOSA, H ;

IRVING, T .

BIOPHYSICAL JOURNAL, 1994, 67 (06) :2411-2421

[20] Intrastrand cross-linked actin between Gln-41 and Cys-374. III. Inhibition of motion and force generation with myosin [J].

Kim, E ;

Bobkova, E ;

Miller, CJ ;

Orlova, A ;

Hegyi, G ;

Egelman, EH ;

Muhlrad, A ;

Reisler, E .

BIOCHEMISTRY, 1998, 37 (51) :17801-17809

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