Bacterial meningitis is associated with high mortality and morbidity rates. Bacterial components induce an overshooting inflammatory reaction, eventually leading to brain damage. Pathological correlates of neurofunctional deficits include cortical necrosis, damage of the inner ear and hippocampal apoptosis. The hippocampal dentate gyrus is important for memory acquisition and harbors a neuronal stem cell niche, thus being potentially well equipped for regeneration. Adjuvant therapies aimed at decreasing the inflammatory reaction, for example, dexamethasone, and those protecting the brain from injury have been evaluated in animal models of the disease. They include nonbacteriolytic antibiotics (e.g., daptomycin), metalloproteinase inhibitors and modulators of the immunological response, for example, granulocyte colony-stimulating factor. Increasing research interest has recently been focused on interventions aimed at supporting regenerative processes.
机构:
Tel Aviv Sourasky Med Ctr, Dana Childrens Hosp, Pediat Infect Dis Unit, Tel Aviv, IsraelSoroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
Grisaru-Soen, Galia
Megged, Orli
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Hebrew Univ Jerusalem, Hadassah Med Sch, Shaare Zedek Med Ctr, Pediat Dept, Jerusalem, Israel
Hebrew Univ Jerusalem, Hadassah Med Sch, Shaare Zedek Med Ctr, Infect Dis Unit, Jerusalem, IsraelSoroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
Megged, Orli
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机构:
Greenberg, David
Dagan, Ron
论文数: 0引用数: 0
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机构:
Soroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, IsraelSoroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
机构:
Marmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Marmara Univ, Pendik Training & Res Hosp, Dept Pediat, Div Pediat Infect Dis, Mimar Sinan St 41, Istanbul, TurkeyMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Soysal, Ahmet
Toprak, Demet Gedikbasi
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机构:
Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USAMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Toprak, Demet Gedikbasi
Turkoglu, Salih
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Anadolu Med Ctr, Kocaeli, TurkeyMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Turkoglu, Salih
Bakir, Mustafa
论文数: 0引用数: 0
h-index: 0
机构:
Marmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, TurkeyMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, VietnamUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Hoang Thanh Hai
Sabiiti, Wilber
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机构:
Univ St Andrews, Div Infect & Global Hlth, Sch Med, St Andrews, Fife, ScotlandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Sabiiti, Wilber
Do Dang Anh Thu
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Univ Oxford, Clin Res Unit, Ho Chi Minh City, VietnamUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Do Dang Anh Thu
Nguyen Hoan Phu
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Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Hosp Trop Dis, Ho Chi Minh City, VietnamUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Nguyen Hoan Phu
Gillespie, Stephen H.
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机构:
Univ St Andrews, Div Infect & Global Hlth, Sch Med, St Andrews, Fife, ScotlandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Gillespie, Stephen H.
Thwaites, Guy E.
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机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Univ Oxford, Nuffield Dept Med, Oxford, EnglandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Thwaites, Guy E.
Nguyen Thuy Thuong Thuong
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机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Univ Oxford, Nuffield Dept Med, Oxford, EnglandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
机构:
Tel Aviv Sourasky Med Ctr, Dana Childrens Hosp, Pediat Infect Dis Unit, Tel Aviv, IsraelSoroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
Grisaru-Soen, Galia
Megged, Orli
论文数: 0引用数: 0
h-index: 0
机构:
Hebrew Univ Jerusalem, Hadassah Med Sch, Shaare Zedek Med Ctr, Pediat Dept, Jerusalem, Israel
Hebrew Univ Jerusalem, Hadassah Med Sch, Shaare Zedek Med Ctr, Infect Dis Unit, Jerusalem, IsraelSoroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
Megged, Orli
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机构:
Greenberg, David
Dagan, Ron
论文数: 0引用数: 0
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机构:
Soroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, IsraelSoroka Univ Med Ctr, Pediat Infect Dis Unit, Beer Sheva, Israel
机构:
Marmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Marmara Univ, Pendik Training & Res Hosp, Dept Pediat, Div Pediat Infect Dis, Mimar Sinan St 41, Istanbul, TurkeyMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Soysal, Ahmet
Toprak, Demet Gedikbasi
论文数: 0引用数: 0
h-index: 0
机构:
Univ Washington, Seattle Childrens Hosp, Seattle, WA 98195 USAMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Toprak, Demet Gedikbasi
Turkoglu, Salih
论文数: 0引用数: 0
h-index: 0
机构:
Anadolu Med Ctr, Kocaeli, TurkeyMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
Turkoglu, Salih
Bakir, Mustafa
论文数: 0引用数: 0
h-index: 0
机构:
Marmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, TurkeyMarmara Univ, Fac Med, Dept Pediat, Div Pediat Infect Dis, Istanbul, Turkey
机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, VietnamUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Hoang Thanh Hai
Sabiiti, Wilber
论文数: 0引用数: 0
h-index: 0
机构:
Univ St Andrews, Div Infect & Global Hlth, Sch Med, St Andrews, Fife, ScotlandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Sabiiti, Wilber
Do Dang Anh Thu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, VietnamUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Do Dang Anh Thu
Nguyen Hoan Phu
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Hosp Trop Dis, Ho Chi Minh City, VietnamUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Nguyen Hoan Phu
Gillespie, Stephen H.
论文数: 0引用数: 0
h-index: 0
机构:
Univ St Andrews, Div Infect & Global Hlth, Sch Med, St Andrews, Fife, ScotlandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Gillespie, Stephen H.
Thwaites, Guy E.
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Univ Oxford, Nuffield Dept Med, Oxford, EnglandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Thwaites, Guy E.
Nguyen Thuy Thuong Thuong
论文数: 0引用数: 0
h-index: 0
机构:
Univ Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam
Univ Oxford, Nuffield Dept Med, Oxford, EnglandUniv Oxford, Clin Res Unit, Ho Chi Minh City, Vietnam