Enantiomeric Natural Products: Occurrence and Biogenesis

被引：226
作者：
Finefield, Jennifer M. [1 ]
Sherman, David H. [2 ,3 ,4 ,6 ]
Kreitman, Martin [5 ]
Williams, Robert M. [1 ,7 ]
机构：
[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA
[2] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA
[3] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA
[4] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA
[5] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA
[6] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA
[7] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA
来源：
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 20期
基金：
美国国家卫生研究院;
关键词：
biosynthesis; enantioselectivity; isolation; natural products; STREPTOMYCES-COELICOLOR A3(2); PRENYLATED INDOLE ALKALOIDS; BIOSYNTHETIC GENE-CLUSTER; SAGE SALVIA-OFFICINALIS; MARINE-DERIVED FUNGUS; PYRAN RING FORMATION; FIR ABIES-GRANDIS; MEDICAGO-SATIVA L; SPONGE-IRCINIA SP; CDNA ISOLATION;
D O I：
10.1002/anie.201107204
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
In nature, chiral natural products are usually produced in optically pure formhowever, occasionally both enantiomers are formed. These enantiomeric natural products can arise from a single species or from different genera and/or species. Extensive research has been carried out over the years in an attempt to understand the biogenesis of naturally occurring enantiomers; however, many fascinating puzzles and stereochemical anomalies still remain.
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收藏
页码：4802 / 4836
页数：35
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