Enantiomeric Natural Products: Occurrence and Biogenesis

被引：230

作者：

Finefield, Jennifer M. ^{[1
]}

Sherman, David H. ^{[2
,3
,4
,6
]}

Kreitman, Martin ^{[5
]}

Williams, Robert M. ^{[1
,7
]}

机构：

[1] Colorado State Univ, Dept Chem, Ft Collins, CO 80523 USA

[2] Univ Michigan, Inst Life Sci, Ann Arbor, MI 48109 USA

[3] Univ Michigan, Dept Med Chem, Ann Arbor, MI 48109 USA

[4] Univ Michigan, Dept Chem, Ann Arbor, MI 48109 USA

[5] Univ Chicago, Dept Ecol & Evolut, Chicago, IL 60637 USA

[6] Univ Michigan, Dept Microbiol & Immunol, Ann Arbor, MI 48109 USA

[7] Univ Colorado, Ctr Canc, Aurora, CO 80045 USA

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2012年 / 51卷 / 20期

基金：

美国国家卫生研究院;

关键词：

biosynthesis; enantioselectivity; isolation; natural products; STREPTOMYCES-COELICOLOR A3(2); PRENYLATED INDOLE ALKALOIDS; BIOSYNTHETIC GENE-CLUSTER; SAGE SALVIA-OFFICINALIS; MARINE-DERIVED FUNGUS; PYRAN RING FORMATION; FIR ABIES-GRANDIS; MEDICAGO-SATIVA L; SPONGE-IRCINIA SP; CDNA ISOLATION;

D O I：

10.1002/anie.201107204

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

In nature, chiral natural products are usually produced in optically pure formhowever, occasionally both enantiomers are formed. These enantiomeric natural products can arise from a single species or from different genera and/or species. Extensive research has been carried out over the years in an attempt to understand the biogenesis of naturally occurring enantiomers; however, many fascinating puzzles and stereochemical anomalies still remain.

引用

页码：4802 / 4836

页数：35

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