Iron-Catalyzed Nitrogen-Directed Coupling of Arene and Aryl Bromides Mediated by Metallic Magnesium

被引：42

作者：

Ilies, Laurean ^{[1
]}

Kobayashi, Motoaki ^{[1
]}

Matsumoto, Arimasa ^{[1
]}

Yoshikai, Naohiko

Nakamura, Eiichi ^{[1
]}

机构：

[1] Univ Tokyo, Dept Chem, Sch Sci, Bunkyo Ku, Tokyo 1130033, Japan

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2012年 / 354卷 / 04期

基金：

日本学术振兴会;

关键词：

aryl bromides; biaryls; C-H activation; iron; magnesium; C-H BOND; DIRECT ARYLATION; ORGANIC-SYNTHESIS; GRIGNARD-REAGENT; CARBON-HYDROGEN; ACTIVATION; IMINES; FUNCTIONALIZATION; BENZAMIDE; PYRIDINES;

D O I：

10.1002/adsc.201100791

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

2-Arylpyridines, 2-alkenylpyridine, and aromatic imines can be coupled with aryl bromides in the presence of an iron catalyst, metallic magnesium, a diamine ligand and an organic dihalide oxidant at 0 degrees C. The use of a 1:1 mixture of tetrahydrofuran and 1,4-dioxane is essential for this C-H bond activation reaction. The reaction has wider scope of the substrate compared with the reaction using a separately prepared Grignard reagent, and proceeds with lower catalyst loading (2.5 mol%).

引用

页码：593 / 596

页数：4

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