Racial disparities and human papillomavirus status in oropharyngeal cancer: A systematic review and meta-analysis

被引：19
作者：
Lenze, Nicholas R. [1 ]
Farquhar, Douglas R. [1 ]
Mazul, Angela L. [2 ]
Masood, Maheer M. [1 ]
Zevallos, Jose P. [3 ]
机构：
[1] Univ N Carolina, Sch Med, Dept Otolaryngol Head & Neck Surg, Chapel Hill, NC 27515 USA
[2] Univ N Carolina, Lineberger Comprehens Canc Ctr, Chapel Hill, NC 27515 USA
[3] Washington Univ, Sch Med, Dept Otolaryngol Head & Neck Surg, 660 S Euclid Ave,Campus Box 8115, St Louis, MO 63110 USA
来源：
HEAD AND NECK-JOURNAL FOR THE SCIENCES AND SPECIALTIES OF THE HEAD AND NECK | 2019年 / 41卷 / 01期
关键词：
health status disparities; human papillomavirus; meta-analysis; oropharyngeal cancer; survival; SQUAMOUS-CELL CARCINOMA; UNITED-STATES; NECK-CANCER; AFRICAN-AMERICANS; ORAL-CAVITY; HEAD; SURVIVAL; OUTCOMES; IMPACT; RACE;
D O I：
10.1002/hed.25414
中图分类号：
R76 [耳鼻咽喉科学];
学科分类号：
100213 ;
摘要：
Background This study used a meta-analysis to quantify the degree to which the racial disparity in overall survival for black versus white Americans with oropharyngeal squamous cell carcinoma (OPSCC) persists after adjusting for human papillomavirus (HPV) status. Methods PubMed/MEDLINE, Cochrane Database of Systematic Reviews, and CINAHLA were searched through November 2017. The PRISMA statement was followed. The pooled hazard ratio (HR) was calculated using a random-effects model. Results Five studies met the inclusion criteria and had suitable data for pooling into the meta-analysis (N = 1153). The pooled HR for overall survival in black versus white Americans with OPSCC after adjusting for HPV status was calculated to be 1.45 (95% confidence interval, 0.87-2.40). Conclusions The difference in survival for black versus white Americans with OPSCC is not significant after adjusting for HPV status but still trends in the direction of a disparity. Additional studies are needed to better characterize this disparity.
引用
收藏
页码：256 / 261
页数：6
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