Physiologically based pharmacokinetic (PBPK) modeling: It is here to stay!

被引:22
作者
Rostami-Hodjegan, Amin [1 ]
Tamai, Ikumi [2 ]
Pang, K. Sandy [3 ]
机构
[1] Univ Manchester, Manchester M13 9PL, Lancs, England
[2] Kanazawa Univ, Kanazawa, Ishikawa 9201192, Japan
[3] Univ Toronto, Leslie Dan Fac Pharm, Toronto, ON M5S 1A1, Canada
关键词
D O I
10.1002/bdd.1776
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
引用
收藏
页码:47 / 50
页数:4
相关论文
共 9 条
[1]   Physiologically based pharmacokinetic (PBPK) modelling tools: how to fit with our needs? [J].
Bouzom, Francois ;
Ball, Kathryn ;
Perdaems, Nathalie ;
Walther, Bernard .
BIOPHARMACEUTICS & DRUG DISPOSITION, 2012, 33 (02) :55-71
[2]   Application of IVIVE and PBPK modeling in prospective prediction of clinical pharmacokinetics: strategy and approach during the drug discovery phase with four case studies [J].
Chen, Yuan ;
Jin, Jin Y. ;
Mukadam, Sophie ;
Malhi, Vikram ;
Kenny, Jane R. .
BIOPHARMACEUTICS & DRUG DISPOSITION, 2012, 33 (02) :85-98
[3]   Utility of a physiologically-based pharmacokinetic (PBPK) modeling approach to quantitatively predict a complex drug-drug-disease interaction scenario for rivaroxaban during the drug review process: implications for clinical practice [J].
Grillo, Joseph A. ;
Zhao, Ping ;
Bullock, Julie ;
Booth, Brian P. ;
Lu, Min ;
Robie-Suh, Kathy ;
Berglund, Eva Gil ;
Pang, K. Sandy ;
Rahman, Atiqur ;
Zhang, Lei ;
Lesko, Lawrence J. ;
Huang, Shiew-Mei .
BIOPHARMACEUTICS & DRUG DISPOSITION, 2012, 33 (02) :99-110
[4]   The Role of Physiologically Based Pharmacokinetic Modeling in Regulatory Review [J].
Huang, S-M ;
Rowland, M. .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2012, 91 (03) :542-549
[5]   Resurgence in the use of physiologically based pharmacokinetic models in pediatric clinical pharmacology: parallel shift in incorporating the knowledge of biological elements and increased applicability to drug development and clinical practice [J].
Johnson, Trevor N. ;
Rostami-Hodjegan, Amin .
PEDIATRIC ANESTHESIA, 2011, 21 (03) :291-301
[6]   Physiologically-Based Pharmacokinetics in Drug Development and Regulatory Science [J].
Rowland, Malcolm ;
Peck, Carl ;
Tucker, Geoffrey .
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, VOL 51, 2011, 2011, 51 :45-73
[7]   Using Simcyp to project human oral pharmacokinetic variability in early drug research to mitigate mechanism-based adverse events [J].
Shaffer, Christopher L. ;
Scialis, Renato J. ;
Rong, Haojing ;
Obach, R. Scott .
BIOPHARMACEUTICS & DRUG DISPOSITION, 2012, 33 (02) :72-84
[8]   From preclinical to human - prediction of oral absorption and drug-drug interaction potential using physiologically based pharmacokinetic (PBPK) modeling approach in an industrial setting: a workflow by using case example [J].
Sinha, Vikash Kumar ;
Snoeys, Jan ;
Van Osselaer, Nancy ;
Van Peer, Achiel ;
Mackie, Claire ;
Heald, Donald .
BIOPHARMACEUTICS & DRUG DISPOSITION, 2012, 33 (02) :111-121
[9]   Applications of Physiologically Based Pharmacokinetic (PBPK) Modeling and Simulation During Regulatory Review [J].
Zhao, P. ;
Zhang, L. ;
Grillo, J. A. ;
Liu, Q. ;
Bullock, J. M. ;
Moon, Y. J. ;
Song, P. ;
Brar, S. S. ;
Madabushi, R. ;
Wu, T. C. ;
Booth, B. P. ;
Rahman, N. A. ;
Reynolds, K. S. ;
Berglund, E. Gil ;
Lesko, L. J. ;
Huang, S-M .
CLINICAL PHARMACOLOGY & THERAPEUTICS, 2011, 89 (02) :259-267