An Aqueous Extract of Withania somnifera Root Inhibits Amyloid β Fibril Formation In Vitro

被引：35
|
作者：
Kumar, Suresh [1 ,2 ]
Harris, Robin J. [3 ,4 ]
Seal, Christopher J. [1 ]
Okello, Edward J. [1 ,5 ]
机构：
[1] Newcastle Univ, Sch Agr Food & Rural Dev, Med Plant Res Grp, Fac Sci Agr & Engn, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[2] GGS Indraprastha Univ, Univ Sch Biotechnol, New Delhi 110075, India
[3] Newcastle Univ, Inst Cell & Mol Biosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[4] Johannes Gutenberg Univ Mainz, Inst Zool, D-55099 Mainz, Germany
[5] Newcastle Univ, Inst Neurosci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
来源：
PHYTOTHERAPY RESEARCH | 2012年 / 26卷 / 01期
关键词：
Alzheimer's disease; amyloid beta; fibrillogenesis; W; somnifera; ALZHEIMERS-DISEASE; OXIDATIVE DAMAGE; PROTEIN; CYTOTOXICITY; MECHANISMS; CLEARANCE; PEPTIDE; BINDING; CORTEX; MICE;
D O I：
10.1002/ptr.3512
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The ability of an aqueous extract of W. somnifera L. Dunal (Family: Solanaceae) roots to inhibit fibril formation by the amyloid-beta peptide in vitro was investigated. W. somnifera is used extensively in traditional Ayurvedic medicine as a nerve tonic with reputed memory enhancing properties. Inhibition of fibrillogenesis measured by transmission electron microscopy and ThT fluorescence assay showed that an aqueous extract of W. somnifera strongly inhibited A beta fibril formation in a concentration-dependent manner, when compared with control samples. These results suggest that the aqueous extract of W. somnifera root has an ability to inhibit the formation of mature amyloid-beta fibrils in vitro, which are known to lead to amyloid plaque formation in vivo. Copyright (C) 2011 John Wiley & Sons, Ltd.
引用
收藏
页码：113 / 117
页数：5
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