Circulating citrulline levels: a biomarker for intestinal functionality assessment

被引：17
作者：
Crenn, Pascal [1 ,2 ]
Hanachi, Mouna [1 ,2 ]
Neveux, Nathalie [2 ,3 ,4 ]
Cynober, Luc [2 ,3 ,4 ]
机构：
[1] Univ Versailles St Quentin En Yvelines, Hop Raymond Poincare, Assistance Publ Hop Paris, Dept Med Aigue Specialisee,EA 4497, Garches, France
[2] Univ Paris 05, Fac Pharm, EA 4466, Paris, France
[3] Hop Cochin, Assistance Publ Hop Paris, F-75674 Paris, France
[4] Hop Hotel Dieu, Serv Interhosp Biochim, Paris, France
来源：
ANNALES DE BIOLOGIE CLINIQUE | 2011年 / 69卷 / 05期
关键词：
citrulline; enterocytes; intestine; intestinal failure; SHORT-BOWEL SYNDROME; BLOOD SPOT CITRULLINE; PLASMA CITRULLINE; ENTEROCYTE MASS; SERUM CITRULLINE; MYELOABLATIVE THERAPY; PARENTERAL-NUTRITION; PROTEIN-METABOLISM; EPITHELIAL DAMAGE; VILLOUS ATROPHY;
D O I：
10.1684/abc.2011.0609
中图分类号：
R446 [实验室诊断]; R-33 [实验医学、医学实验];
学科分类号：
1001 ;
摘要：
Circulating citrulline is emerging as an innovating biomarker candidate for assessment of intestinal function. Amino acid synthesized by enterocytes of intestinal mucosal, citrulline is not included in proteins or nutrition products and is a precursor for production of arginine by the kidney. Plasma citrulline is, in clinical situation, an established biomarker of enterocyte functional metabolic mass (trophicity) in children and in adult patients due to its high relation to active functional small bowel remnant length in intestinal diseases (short bowel, extensive enteropathies, intestinal toxicity of chemotherapy and radiotherapy. Plasma citrulline concentration (30-50 mu mol/L), independent of nutritional status, if less than 10 mu mol/L can give an objective threshold for nutrition parenteral use in case of intestinal failure due to enterocyte abnormalities or lack. Its regular dosage allows the monitoring of intestinal function except in case of significant renal failure.
引用
收藏
页码：513 / 521
页数：9
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