Altered Resting-State Functional Connectivity of the Frontal-Striatal Reward System in Social Anxiety Disorder

被引:36
作者
Manning, Joshua [1 ,3 ]
Reynolds, Gretchen [2 ,4 ]
Saygin, Zeynep M. [1 ,3 ]
Hofmann, Stefan G. [4 ]
Pollack, Mark [5 ]
Gabrieli, John D. E. [1 ,2 ,3 ]
Whitfield-Gabrieli, Susan [1 ,2 ,3 ]
机构
[1] MIT, McGovern Inst Brain Res, Cambridge, MA 02139 USA
[2] MIT, Poitras Ctr Affect Disorders Res, Cambridge, MA 02139 USA
[3] MIT, Dept Brain & Cognit Sci, Cambridge, MA 02139 USA
[4] Boston Univ, Dept Psychol, Boston, MA 02215 USA
[5] Rush Univ, Med Ctr, Chicago, IL 60612 USA
基金
美国国家卫生研究院;
关键词
VENTROMEDIAL PREFRONTAL CORTEX; ANTERIOR CINGULATE; HUMAN BRAIN; ANTICIPATION; ADOLESCENTS;
D O I
10.1371/journal.pone.0125286
中图分类号
O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];
学科分类号
07 ; 0710 ; 09 ;
摘要
We investigated differences in the intrinsic functional brain organization (functional connectivity) of the human reward system between healthy control participants and patients with social anxiety disorder. Functional connectivity was measured in the resting-state via functional magnetic resonance imaging (fMRI). 53 patients with social anxiety disorder and 33 healthy control participants underwent a 6-minute resting-state fMRI scan. Functional connectivity of the reward system was analyzed by calculating whole-brain temporal correlations with a bilateral nucleus accumbens seed and a ventromedial prefrontal cortex seed. Patients with social anxiety disorder, relative to the control group, had (1) decreased functional connectivity between the nucleus accumbens seed and other regions associated with reward, including ventromedial prefrontal cortex; (2) decreased functional connectivity between the ventromedial prefrontal cortex seed and lateral prefrontal regions, including the anterior and dorsolateral prefrontal cortices; and (3) increased functional connectivity between both the nucleus accumbens seed and the ventromedial prefrontal cortex seed with more posterior brain regions, including anterior cingulate cortex. Social anxiety disorder appears to be associated with widespread differences in the functional connectivity of the reward system, including markedly decreased functional connectivity between reward regions and between reward regions and lateral prefrontal cortices, and markedly increased functional connectivity between reward regions and posterior brain regions.
引用
收藏
页数:15
相关论文
共 50 条
[41]   Predicting human resting-state functional connectivity from structural connectivity [J].
Honey, C. J. ;
Sporns, O. ;
Cammoun, L. ;
Gigandet, X. ;
Thiran, J. P. ;
Meuli, R. ;
Hagmann, P. .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2009, 106 (06) :2035-2040
[42]   Altered functional connectivity of resting-state networks and the correlation with clinical characteristics in intermittent exotropia adult patients: a resting-state magnetic resonance imaging study [J].
Li, Huixin ;
Li, Wei ;
Hong, Jie ;
Liu, Jiawen ;
Hao, Jie ;
Dai, Wei ;
Liu, Zhaohui ;
Fu, Jing .
BMC OPHTHALMOLOGY, 2024, 24 (01)
[43]   Maternal trait anxiety symptoms, frontolimbic resting-state functional connectivity, and cognitive development in infancy [J].
Dufford, Alexander J. ;
Salzwedel, Andrew P. ;
Gilmore, John H. ;
Gao, Wei ;
Kim, Pilyoung .
DEVELOPMENTAL PSYCHOBIOLOGY, 2021, 63 (06)
[44]   Altered Functional Connectivity of the Primary Visual Cortex in Adult Comitant Strabismus: A Resting-State Functional MRI Study [J].
Yan, Xiaohe ;
Wang, Yun ;
Xu, Lijuan ;
Liu, Yong ;
Song, Shaojie ;
Ding, Kun ;
Zhou, Yuan ;
Jiang, Tianzi ;
Lin, Xiaoming .
CURRENT EYE RESEARCH, 2019, 44 (03) :316-323
[45]   Resting-state abnormalities in functional connectivity of the default mode network in autism spectrum disorder: a meta-analysis [J].
Wang, Qing ;
Li, Hua-Yun ;
Li, Yun-Da ;
Lv, Ya-Ting ;
Ma, Hui-Bin ;
Xiang, An-Feng ;
Jia, Xi-Ze ;
Liu, Dong-Qiang .
BRAIN IMAGING AND BEHAVIOR, 2021, 15 (05) :2583-2592
[46]   Aberrant connectivity of resting-state networks in borderline personality disorder [J].
Wolf, Robert Christian ;
Sambataro, Fabio ;
Vasic, Nenad ;
Schmid, Markus ;
Thomann, Philipp Arthur ;
Bienentreu, Sara Doris ;
Wolf, Nadine Donata .
JOURNAL OF PSYCHIATRY & NEUROSCIENCE, 2011, 36 (06) :402-411
[47]   Functional parcellation of the hippocampus from resting-state dynamic functional connectivity [J].
Zhong, Qi ;
Xu, Huaze ;
Qin, Jian ;
Zeng, Ling -Li ;
Hu, Dewen ;
Shen, Hui .
BRAIN RESEARCH, 2019, 1715 :165-175
[48]   Discriminating Suicide Attempters and Predicting Suicide Risk Using Altered Frontolimbic Resting-State Functional Connectivity in Patients With Bipolar II Disorder [J].
Zhu, Rongxin ;
Tian, Shui ;
Wang, Huan ;
Jiang, Haiteng ;
Wang, Xinyi ;
Shao, Junneng ;
Wang, Qiang ;
Yan, Rui ;
Tao, Shiwan ;
Liu, Haiyan ;
Yao, Zhijian ;
Lu, Qing .
FRONTIERS IN PSYCHIATRY, 2020, 11
[49]   Resting-state connectivity of the amygdala is altered following Pavlovian fear conditioning [J].
Schultz, Douglas H. ;
Balderston, Nicholas L. ;
Helmstetter, Fred J. .
FRONTIERS IN HUMAN NEUROSCIENCE, 2012, 6
[50]   Cerebro-cerebellar Resting-State Functional Connectivity in Children and Adolescents with Autism Spectrum Disorder [J].
Khan, Amanda J. ;
Nair, Aarti ;
Keown, Christopher L. ;
Datko, Michael C. ;
Lincoln, Alan J. ;
Mueller, Ralph-Axel .
BIOLOGICAL PSYCHIATRY, 2015, 78 (09) :625-634