Actively targeted delivery of SN38 by ultrafine iron oxide nanoparticle for treating pancreatic cancer
被引:8
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作者:
Xue, Ting
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Southern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R ChinaSouthern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
Xue, Ting
[1
]
Xu, Peijia
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Southern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R ChinaSouthern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
Xu, Peijia
[1
]
Padelford, Jonathan
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机构:
LLC 5M Biomed, Atlanta, GA 30333 USASouthern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
Padelford, Jonathan
[2
]
Xue, Xingkui
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Southern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R ChinaSouthern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
Xue, Xingkui
[1
]
Wu, Alyssa Y.
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Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USASouthern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
Wu, Alyssa Y.
[3
]
Li, Yuancheng
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机构:
LLC 5M Biomed, Atlanta, GA 30333 USA
Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USASouthern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
Li, Yuancheng
[2
,3
]
Wang, Liya
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Southern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R ChinaSouthern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
Wang, Liya
[1
]
机构:
[1] Southern Med Univ, Affiliated Longhua Peoples Hosp, Sch Clin Med 3, Dept Radiol, Shenzhen 518109, Peoples R China
[2] LLC 5M Biomed, Atlanta, GA 30333 USA
[3] Emory Univ, Dept Radiol & Imaging Sci, Atlanta, GA 30322 USA
Pancreatic cancer remains one of the most lethal cancers largely due to the inefficient delivery of therapeutics. Nanomaterials have been extensively investigated as drug delivery platforms, showing improved drug pharmacodynamics and pharmacokinetics. However, their applications in pancreatic cancer have not yet been successful due to limited tumor delivery caused by dense tumor stroma and distorted tumor vasculatures. Meanwhile, smaller-sized nanomaterials have shown improved tumor delivery and retention in various tumors, including pancreatic tumors, suggesting their potential in enhancing drug delivery. An ultrafine iron oxide nanoparticle (uIONP) was used to encapsulate 7-ethyl-10-hydroxyl camptothecin (SN38), the water-insoluble active metabolite of pancreatic cancer chemotherapy drug irinotecan. Insulin-like growth factor 1 (IGF-1) was conjugated to uIONP as a ligand for targeting pancreatic cancer cells overexpressing IGF-1 receptor (IGF1R). The SN38 loading and release profile were characterized. The pancreatic cancer cell targeting using IGF1-uIONP/SN38 and subsequently induced cell apoptosis were also investigated. IGF1-uIONP/SN38 demonstrated a stable drug loading in physiological pH with the loading efficiency of 68.2 +/- 3.5% (SN38/Fe, wt%) and < 7% release for 24 h. In tumor-interstitial- and lysosomal-mimicking pH (6.5 and 5.5), 52.2 and 91.3% of encapsulated SN38 were released over 24 h. The IGF1-uIONP/SN38 exhibited specific receptor-mediated cell targeting and cytotoxicity Ato MiaPaCa-2 and Panc02 pancreatic cancer cells with IC50 of 11.8 +/- 2.3 and 20.8 +/- 3.5 nM, respectively, but not to HEK293 human embryonic kidney cells. IGF1-uIONP significantly improved the targeted SN38 delivery to pancreatic cancer cells, holding the potential for in vivo theranostic applications.
机构:
Saveetha Engn Coll, Dept Phys, Chennai 602105, IndiaSaveetha Engn Coll, Dept Phys, Chennai 602105, India
Sukumar, Kalpana
Bharathi, Muruganantham
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Karpagam Acad Higher Educ, Ctr Drug Discovery, Dept Biochem, Coimbatore 641021, Tamil Nadu, IndiaSaveetha Engn Coll, Dept Phys, Chennai 602105, India
Bharathi, Muruganantham
Hirad, Abdurahman Hajinur
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King Saud Univ, Coll Sci, Dept Bot & Microbiol, POB 2455, Riyadh 11451, Saudi ArabiaSaveetha Engn Coll, Dept Phys, Chennai 602105, India
Hirad, Abdurahman Hajinur
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Alarfaj, Abdullah A.
Hussein-Al-Ali, Samer Hasan
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Isra Univ, Fac Sci, Dept Chem, Amman 11622, JordanSaveetha Engn Coll, Dept Phys, Chennai 602105, India
Hussein-Al-Ali, Samer Hasan
Surya, Parthasarathy
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Saveetha Univ, Saveetha Dent Coll & Hosp, Saveetha Inst Med & Tech Sci, Dept Res Analyt, Chennai 600077, Tamil Nadu, IndiaSaveetha Engn Coll, Dept Phys, Chennai 602105, India
机构:
Harvard Radiat Oncol Program, Boston, MA USA
MIT, Harvard Ctr Nanotechnol Excellence, Dept Chem Engn, Cambridge, MA USAHarvard Radiat Oncol Program, Boston, MA USA
Wang, A. Z.
Bagalkot, V.
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Gwangju Inst Sci & Technol, Dept Life Sci, Seoul, South KoreaHarvard Radiat Oncol Program, Boston, MA USA
Bagalkot, V.
Gu, F.
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MIT, Harvard Ctr Nanotechnol Excellence, Dept Chem Engn, Cambridge, MA USAHarvard Radiat Oncol Program, Boston, MA USA
Gu, F.
Alexis, F.
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MIT, Harvard Ctr Nanotechnol Excellence, Dept Chem Engn, Cambridge, MA USAHarvard Radiat Oncol Program, Boston, MA USA
Alexis, F.
Vasilliou, C.
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MIT, Harvard Ctr Nanotechnol Excellence, Dept Chem Engn, Cambridge, MA USAHarvard Radiat Oncol Program, Boston, MA USA
Vasilliou, C.
Cima, M.
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MIT, Harvard Ctr Nanotechnol Excellence, Dept Chem Engn, Cambridge, MA USAHarvard Radiat Oncol Program, Boston, MA USA
Cima, M.
Jon, S.
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Gwangju Inst Sci & Technol, Dept Life Sci, Seoul, South KoreaHarvard Radiat Oncol Program, Boston, MA USA
Jon, S.
Farokhzad, O.
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机构:
Brigham & Womens Hosp, Harvard Med Sch, Dept Anaesthesiol, Boston, MA USA
MIT, Harvard Ctr Nanotechnol Excellence, Cambridge, MA USAHarvard Radiat Oncol Program, Boston, MA USA
Farokhzad, O.
INTERNATIONAL JOURNAL OF RADIATION ONCOLOGY BIOLOGY PHYSICS,
2007,
69
(03):
: S110
-
S111
机构:
Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Gupta, Jagriti
Prakash, Anand
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Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Prakash, Anand
Jaiswal, Manish K.
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Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Jaiswal, Manish K.
Agarrwal, Atanuu
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Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
Agarrwal, Atanuu
Bahadur, D.
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Indian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, IndiaIndian Inst Technol, Dept Met Engn & Mat Sci, Bombay 400076, Maharashtra, India
机构:
Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Mahajan, Ujjwal M.
Teller, Steffen
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Teller, Steffen
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Sendler, Matthias
Palankar, Raghavendra
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ZIK HIKE Ctr Innovat Competence Humoral Immune Re, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Palankar, Raghavendra
van den Brandt, Cindy
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
van den Brandt, Cindy
Schwaiger, Theresa
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Schwaiger, Theresa
Kuehn, Jens-Peter
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Radiol & Neuroradiol, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Kuehn, Jens-Peter
Ribback, Silvia
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Inst Pathol, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Ribback, Silvia
Gloeckl, Gunnar
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Ernst Moritz Arndt Univ Greifswald, Inst Pharm, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Gloeckl, Gunnar
Evert, Matthias
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Inst Pathol, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Evert, Matthias
Weitschies, Werner
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Ernst Moritz Arndt Univ Greifswald, Inst Pharm, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Weitschies, Werner
Hosten, Norbert
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Radiol & Neuroradiol, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Hosten, Norbert
Dombrowski, Frank
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Ernst Moritz Arndt Univ Greifswald, Inst Pharm, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Dombrowski, Frank
Delcea, Mihaela
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ZIK HIKE Ctr Innovat Competence Humoral Immune Re, Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Delcea, Mihaela
Weiss, Frank-Ulrich
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Weiss, Frank-Ulrich
Lerch, Markus M.
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany
Lerch, Markus M.
Mayerle, Julia
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Ernst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, GermanyErnst Moritz Arndt Univ Greifswald, Univ Med, Dept Med A, Ferdinand Sauerbruchstr, D-17475 Greifswald, Germany