Changes of catalase activity after ischemia-reperfusion in rat retina

被引:10
作者
Lewden, O
Garcher, C
Morales, C
Javouhey, A
Rochette, L
Bron, AM
机构
[1] UNIV DIJON, GEN HOSP, DEPT OPHTHALMOL, F-21000 DIJON, FRANCE
[2] UNIV BURGUNDY, LAB CARDIOVASC PHYSIOL, DIJON, FRANCE
关键词
catalase; retina; ischemia; reperfusion;
D O I
10.1159/000267924
中图分类号
R77 [眼科学];
学科分类号
100212 ;
摘要
Catalase activity was evaluated in Long Evans rat retina after ischemia and reperfusion. Ischemia was induced by ligation of the optic nerve and vessels. Rats were sacrificed after 15 and 120 min of reperfusion, respectively. Catalase activity was assessed by Claiborne's method and was expressed as U/mg of protein. In the first group, retinas of each animal were pooled. In the second group, ischemia was induced in the right eye with the left eye serving as control. In the first group, enzyme activity was 7.39 +/- 0.26 (n = 11), 7.67 +/- 0.27 (n = 9) and 9.15 +/- 0.45 (n = 7) for the sham-operated, 15- and 120-min reperfusion groups, respectively. There was a significant difference between the control and 120-min reperfusion groups (p < 0.001). In the second group, there was a significant (p < 0.01) increase in catalase activity in the ischemic eye compared to the non-ischemic eye after 15 (n = 7) and 120 min (n = 9) of reperfusion. These findings may suggest a rapid activation of catalase activity during the ischemia-reperfusion sequence.
引用
收藏
页码:331 / 335
页数:5
相关论文
共 16 条
[1]   THE DISTRIBUTION OF PEROXIDE REGULATING ENZYMES IN THE CANINE EYE [J].
ARMSTRONG, D ;
SANTANGELO, G ;
CONNOLE, E .
CURRENT EYE RESEARCH, 1981, 1 (04) :225-242
[2]  
Claiborne A., 1985, Handbook of Methods of Oxygen Radicals Research, DOI DOI 10.1016/0531-5565(85)90021-X
[3]   A PAIRED-COMPARISON OF 2 MODELS OF EXPERIMENTAL RETINAL ISCHEMIA [J].
GEHLBACH, PL ;
PURPLE, RL .
CURRENT EYE RESEARCH, 1994, 13 (08) :597-602
[4]   MANNITOL, DEXTROMETHORPHAN, AND CATALASE MINIMIZE ISCHEMIC DAMAGE TO RETINAL-PIGMENT EPITHELIUM AND RETINA [J].
GUPTA, LY ;
MARMOR, MF .
ARCHIVES OF OPHTHALMOLOGY, 1993, 111 (03) :384-388
[5]   QUANTITATION OF ISCHEMIC DAMAGE IN THE RAT RETINA [J].
HUGHES, WF .
EXPERIMENTAL EYE RESEARCH, 1991, 53 (05) :573-582
[6]   ANTIOXIDANT ENZYMES IN THE AGING HUMAN RETINAL-PIGMENT EPITHELIUM [J].
LILES, MR ;
NEWSOME, DA ;
OLIVER, PD .
ARCHIVES OF OPHTHALMOLOGY, 1991, 109 (09) :1285-1288
[7]  
NAYAK MS, 1993, INVEST OPHTH VIS SCI, V34, P2018
[8]   HYDROXYL RADICAL GENERATION IN THE CAT RETINA DURING REPERFUSION FOLLOWING ISCHEMIA [J].
OPHIR, A ;
BERENSHTEIN, E ;
KITROSSKY, N ;
BERMAN, ER ;
PHOTIOU, S ;
ROTHMAN, Z ;
CHEVION, M .
EXPERIMENTAL EYE RESEARCH, 1993, 57 (03) :351-357
[9]  
RAO NA, 1987, ARCH OPHTHALMOL-CHIC, V105, P1712
[10]   MEASUREMENT OF PROTEIN USING BICINCHONINIC ACID [J].
SMITH, PK ;
KROHN, RI ;
HERMANSON, GT ;
MALLIA, AK ;
GARTNER, FH ;
PROVENZANO, MD ;
FUJIMOTO, EK ;
GOEKE, NM ;
OLSON, BJ ;
KLENK, DC .
ANALYTICAL BIOCHEMISTRY, 1985, 150 (01) :76-85