The Implications of Brain MRI in Autism Spectrum Disorder

被引:13
作者
Cooper, Alison S. [1 ,2 ]
Friedlaender, Eron [1 ]
Levy, Susan E. [3 ]
Shekdar, Karuna V. [4 ]
Bradford, Andrea Bennett [5 ]
Wells, Kimberly E. [1 ,6 ]
Mollen, Cynthia [1 ]
机构
[1] Univ Penn, Childrens Hosp Philadelphia, Dept Pediat, Div Pediat Emergency Med,Perelman Sch Med, Philadelphia, PA 19104 USA
[2] Steven & Alexandra Cohen Childrens Med Ctr New Yo, Pediat Emergency Dept, New Hyde Pk, NY USA
[3] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Div Dev & Behav Pediat, Philadelphia, PA 19104 USA
[4] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Radiol,Div Neuroradiol, Philadelphia, PA 19104 USA
[5] Univ Penn, Childrens Hosp Philadelphia, Perelman Sch Med, Dept Pediat,Div Gen Pediat, Philadelphia, PA 19104 USA
[6] Western Michigan Univ, Homer Stryker MD Sch Med, Kalamazoo, MI 49008 USA
关键词
autism spectrum disorder; MRI brain; MRI referral; pediatric; sedation; ADVERSE-EVENTS; DIAGNOSIS; CHILDREN; IMAGES;
D O I
10.1177/0883073816665548
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Our objective was to describe the types of providers who refer children with autism spectrum disorder (ASD) for brain magnetic resonance imaging (MRI), the referral reason, and MRI results. The most common referral reasons were autism spectrum disorder with seizures (33.7%), autism spectrum disorder alone (26.3%), and autism spectrum disorder with abnormal neurologic examination or preexisting finding (24%). Neurology (62.5%), general pediatric (22.3%), and developmental/behavioral practitioners (8.9%) referred the most patients. The prevalence of definite pathology was highest in children referred for autism spectrum disorder with abnormal neurologic examination/preexisting finding (26.2%, 95% CI: 16.8%-36%), headaches (25.7%, 95% CI: 11.2%-40.2%), or seizures (22%, 95% CI: 14.6%-29.5%), and was lowest in children referred for autism spectrum disorder alone (6.5%, 95% CI: 1.5%-11.6%). We concluded that there is a low prevalence of definite pathology in children with autism spectrum disorder undergoing brain MRI. In children with abnormal neurologic examination or preexisting finding, seizures, or headaches, one may consider performing brain MRI given the higher prevalence of pathology.
引用
收藏
页码:1611 / 1616
页数:6
相关论文
共 18 条
[1]  
[Anonymous], 2000, DIAGN STAT MAN MENT, DOI DOI 10.1176/APPI.BOOKS.9780890425787
[2]   Prospective analysis on brain magnetic resonance imaging in children [J].
Biebl, Ariane ;
Frechinger, Bettina ;
Fellner, Christine Maria ;
Ehrenmueller, Margit ;
Povysil, Brigitte ;
Fellner, Franz ;
Schmitt, Klaus ;
Furthner, Dieter .
EUROPEAN JOURNAL OF PAEDIATRIC NEUROLOGY, 2015, 19 (03) :349-353
[3]  
Carter MJ, 2014, THER RECREAT J, V48, P275
[4]   Structural MRI in Autism Spectrum Disorder [J].
Chen, Rong ;
Jiao, Yun ;
Herskovits, Edward H. .
PEDIATRIC RESEARCH, 2011, 69 (05) :63R-68R
[5]   Incidence and nature of adverse events during pediatric sedation/anesthesia for procedures outside the operating room: Report from the pediatric sedation research consortium [J].
Cravero, Joseph P. ;
Blike, George T. ;
Beach, Michael ;
Gallagher, Susan M. ;
Hertzog, James H. ;
Havidich, Jeana E. ;
Gelman, Barry .
PEDIATRICS, 2006, 118 (03) :1087-1096
[6]   Describing the Brain in Autism in Five Dimensions-Magnetic Resonance Imaging-Assisted Diagnosis of Autism Spectrum Disorder Using a Multiparameter Classification Approach [J].
Ecker, Christine ;
Marquand, Andre ;
Mourao-Miranda, Janaina ;
Johnston, Patrick ;
Daly, Eileen M. ;
Brammer, Michael J. ;
Maltezos, Stefanos ;
Murphy, Clodagh M. ;
Robertson, Dene ;
Williams, Steven C. ;
Murphy, Declan G. M. .
JOURNAL OF NEUROSCIENCE, 2010, 30 (32) :10612-10623
[7]   Practice parameter: Screening and diagnosis of autism - Report of the Quality Standards Subcommittee of the American Academy of Neurology and the Child Neurology Society [J].
Filipek, PA ;
Accardo, PJ ;
Ashwal, S ;
Baranek, GT ;
Cook, EH ;
Dawson, G ;
Gordon, B ;
Gravel, JS ;
Johnson, CP ;
Kallen, RJ ;
Levy, SE ;
Minshew, NJ ;
Ozonoff, S ;
Prizant, BM ;
Rapin, I ;
Rogers, SJ ;
Stone, WL ;
Teplin, SW ;
Tuchman, RF ;
Volkmar, FR .
NEUROLOGY, 2000, 55 (04) :468-479
[9]   Autism and Asperger syndrome: coexistence with other clinical disorders [J].
Gillberg, C ;
Billstedt, E .
ACTA PSYCHIATRICA SCANDINAVICA, 2000, 102 (05) :321-330
[10]   Atypical neural networks for social orienting in autism spectrum disorders [J].
Greene, Deanna J. ;
Colich, Natalie ;
Iacoboni, Marco ;
Zaidel, Eran ;
Bookheimer, Susan Y. ;
Dapretto, Mirella .
NEUROIMAGE, 2011, 56 (01) :354-362