Population-based study of α- and γ-tocopherol in plasma and adipose tissue as biomarkers of intake in Costa Rican adults

被引:0
作者
El-Sohemy, A
Baylin, A
Ascherio, A
Kabagambe, E
Spiegelman, D
Campos, H
机构
[1] Harvard Univ, Sch Publ Hlth, Dept Nutr, Boston, MA 02115 USA
[2] Univ Costa Rica, Inst Invest Salud, San Pedro, Costa Rica
关键词
vitamin E; biomarkers; alpha-tocopherol; gamma-tocopherol; adipose tissue; alpha-tocopherol transfer protein; food-frequency questionnaire; Hispanics; Costa Rica;
D O I
暂无
中图分类号
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号
100403 ;
摘要
Background: gamma -Tocopherol is the most abundant form of vitamin E in the US diet, but alpha -tocopherol concentrations are the highest in plasma and tissues. Although plasma and adipose tissue concentrations of alpha -tocopherol have been used as biomarkers of intake, the relation between gamma -tocopherol intake and concentrations in plasma and adipose tissue is unknown. Objective: Our goal was to investigate in a randomly selected population from Costa Rica whether plasma or adipose tissue concentrations of alpha- and gamma -tocopherol are suitable biomarkers of intake. Design: A total of 361 men ((x) over bar +/- SD age: 55 +/- 11 y) and 121 women (aged 59 +/- 10 y) completed a 135-item food-frequency questionnaire and provided a fasting blood sample and adipose tissue biopsy sample. Results: Dietary gamma -tocopherol correlated with adipose tissue (r=0.37, P<0.001) and plasma (r=0.42, P<0.001) concentrations, regardless of supplement use. Dietary alpha -tocopherol correlated poorly with adipose tissue (r=0.15, P<0.01) and plasma (r=0.16, P<0.001) concentrations, and these correlations were even lower when users of vitamin supplements (n=24) were excluded (adipose tissue: r=0.10, P<0.05; plasma: r=0.09, P<0.05). Compared with subjects who reported palm shortening (36%) as the major type of fat used for cooking, subjects using soybean oil (52%) had higher amounts of both alpha- and gamma -tocopherol in their diets. However, only gamma -tocopherol concentrations were higher in the plasma and adipose tissue of soybean oil users. Conclusions: Plasma and adipose tissue concentrations of gamma -tocopherol are equally good biomarkers of intake. The weak associations between alpha -tocopherol intake and plasma or adipose tissue concentrations suggest that these biomarkers are influenced more by factors other than alpha -tocopherol intake.
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页码:356 / 363
页数:8
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