TNF-α (G-308A) Polymorphism, Circulating Levels of TNF-α and IGF-1: Risk Factors for Ischemic Stroke-An Updated Meta-Analysis

被引：13
作者：
Duan, Ranran [1 ]
Wang, Na [2 ]
Shang, Yanan [3 ]
Li, Hengfen [3 ]
Liu, Qian [3 ]
Li, Li [4 ]
Zhao, Xiaofeng [3 ]
机构：
[1] Zhengzhou Univ, Affiliated Hosp 1, Dept Neurol, Zhengzhou, Peoples R China
[2] Zhengzhou Univ, Affiliated Hosp 2, Dept Neurorehabil, Zhengzhou, Peoples R China
[3] Zhengzhou Univ, Affiliated Hosp 1, Dept Psychiat, Zhengzhou, Peoples R China
[4] Capital Med Univ, Beijing Friendship Hosp, Dept Anesthesiol, Beijing, Peoples R China
来源：
FRONTIERS IN AGING NEUROSCIENCE | 2022年 / 14卷
基金：
英国科研创新办公室;
关键词：
TNF-a; IGF-1; ischemic stroke; meta-analysis; gene polymorphism; TUMOR-NECROSIS-FACTOR; GROWTH-FACTOR-I; SERUM-LEVELS; NOREPINEPHRINE TRANSPORTER; INFLAMMATORY RESPONSE; RECEPTOR ANTAGONIST; GENE POLYMORPHISMS; LEVELS CORRELATE; MESSENGER-RNA; BRAIN;
D O I：
10.3389/fnagi.2022.831910
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Objective:Accumulated studies have explored gene polymorphisms and circulating levels of tumor necrosis factor (TNF)-alpha and insulin-like growth factor (IGF)-1 in the etiology of ischemic stroke (IS). Of the numerous etiopathological factors for IS, a single-nucleotide polymorphism (SNP) rs1800629 located in the TNF-alpha gene promoter region and increased levels of TNF-alpha were found to be associated with IS in different ethnic backgrounds. However, the published results are inconsistent and inconclusive. The primary objective of this meta-analysis was to investigate the concordance between rs1800629 polymorphism and IS. A secondary aim was to explore circulating levels of TNF-alpha and IGF-1 with IS in different ethnic backgrounds and different sourced specimens. Methods: In this study, we examined whether rs1800629 genetic variant and levels of TNF-alpha and IGF-1 were related to the etiology of IS by performing a meta-analysis. Relevant case-control studies were retrieved by database searching and systematically selected according to established inclusion criteria. Results:A total of 47 articles were identified that explored the relationship between the rs1800629 polymorphism and levels of TNF-alpha and IGF-1 with IS risk susceptibility. Statistical analyses revealed a significant association between the rs1800629 polymorphism and levels of TNF-alpha and IGF-1 with IS pathogenesis. Conclusion:Our findings demonstrated that the TNF-alpha rs1800629 polymorphism, the increased levels of TNF-alpha, and decreased levels of IGF-1 were involved in the etiology of IS.
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页数：13
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