Segregation into Chiral Enantiomeric Conformations of an Achiral Molecule by Concomitant Polymorphism

被引：14

作者：

Rajbongshi, Basanta Kumar ^{[1
]}

Nair, Nisanth N. ^{[1
]}

Nethaji, M. ^{[2
]}

Ramanathan, Gurunath ^{[1
]}

机构：

[1] Indian Inst Technol, Dept Chem, Kanpur 208016, Uttar Pradesh, India

[2] Indian Inst Sci, Dept Inorgan & Phys Chem, Bangalore 560012, Karnataka, India

来源：

CRYSTAL GROWTH & DESIGN | 2012年 / 12卷 / 04期

关键词：

GREEN FLUORESCENT PROTEIN; CRYSTAL-STRUCTURES; 4,4-DIPHENYL-2,5-CYCLOHEXADIENONE;

D O I：

10.1021/cg201313g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An analogue of the green fluorescent protein (GFP) luminophore crystallizes from a methanol solution impregnated with dichloromethane, into a pair of chiral crystals. Thermal analysis, fluorescence emission studies, and crystal packing analysis show that the two crystals are different materials. The two polymorphs arise from the rotation of a monosubstituted benzene ring about a C-N bond which results in the formation of two strong bifurcated C-H center dot center dot center dot O intermolecular bonds to oxygen O(6). The color difference has been ascribed to a difference in the packing of the two crystal forms. Theoretical studies supported by low temperature NMR show low kinetic energy barriers (similar to 10 kJ mol(-1)) separating the asymmetric units of the two crystal structures, suggesting that the driving force for the polymorphism could be the result of packing of two different asymmetric units.

引用

页码：1823 / 1829

页数：7