An efficient, one-pot synthesis of spiro[dihydropyridine-oxindole] compounds under catalyst-free conditions

被引：10

作者：

Lu, Guo-ping ^{[1
]}

Cai, Chun ^{[1
]}

机构：

[1] Nanjing Univ Sci & Technol, Coll Chem Engn, Nanjing 210094, Peoples R China

来源：

JOURNAL OF CHEMICAL RESEARCH | 2011年 / 09期

关键词：

spiro[dihydropyridine-oxindole; poly (ethylene glycol); catalyst-free; multicomponent reaction; 3-COMPONENT METHOD; DERIVATIVES; LIBRARY;

D O I：

10.3184/174751911X13157531279974

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

An efficient one-pot synthesis of the biologically important spiro[dihydropyridine-oxindole] scaffolds from isatins, 2-naphthylamine and 1,3-dicarbonyl compounds in poly (ethylene glycol) 400/H2O under catalyst-free conditions is described. The reaction is free of catalysts and toxic solvents, operates under neutral conditions and allows for ease of product isolation, making it more environmentally friendly and suitable for large-scale operations.

引用

页码：547 / 551

页数：5

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