Alcohol consumption and breast cancer risk by estrogen receptor status: in a pooled analysis of 20 studies

被引：97

作者：

Jung, Seungyoun ^{[1
,2
,3
]}

Wang, Molin ^{[2
,4
]}

Anderson, Kristin ^{[5
,6
]}

Baglietto, Laura ^{[7
,8
]}

Bergkvist, Leif ^{[9
,10
]}

Bernstein, Leslie ^{[11
,12
]}

van den Brandt, Piet A. ^{[13
]}

Brinton, Louise ^{[14
]}

Buring, Julie E. ^{[2
,15
]}

Eliassen, A. Heather ^{[2
,16
,17
]}

Falk, Roni ^{[14
]}

Gapstur, Susan M. ^{[18
]}

Giles, Graham G. ^{[7
,8
]}

Goodman, Gary ^{[19
]}

Hoffman-Bolton, Judith ^{[20
]}

Horn-Ross, Pamela L. ^{[21
]}

Inoue, Manami ^{[22
,23
]}

Kolonel, Laurence N. ^{[24
]}

Krogh, Vittorio ^{[25
]}

Lof, Marie ^{[26
]}

Maas, Paige ^{[14
]}

Miller, Anthony B. ^{[27
]}

Neuhouser, Marian L. ^{[19
]}

Park, Yikyung ^{[28
]}

Robien, Kim ^{[29
]}

Rohan, Thomas E. ^{[30
]}

Scarmo, Stephanie ^{[31
]}

Schouten, Leo J. ^{[13
]}

Sieri, Sabina ^{[25
]}

Stevens, Victoria L. ^{[18
]}

Tsugane, Schoichiro ^{[22
]}

Visvanathan, Kala ^{[20
]}

Wilkens, Lynne R. ^{[24
]}

Wolk, Alicja ^{[32
]}

Weiderpass, Elisabete ^{[33
,34
,35
,36
]}

Willett, Walter C. ^{[1
,2
,16
,17
]}

Zeleniuch-Jacquotte, Anne ^{[31
]}

Zhang, Shumin M. ^{[15
]}

Zhang, Xuehong ^{[16
,17
]}

Ziegler, Regina G. ^{[14
]}

Smith-Warner, Stephanie A. ^{[1
,2
]}

机构：

[1] Harvard TH Chan Sch Publ Hlth, Dept Nutr, Boston, MA USA

[2] Harvard TH Chan Sch Publ Hlth, Dept Epidemiol, Boston, MA USA

[3] Univ Maryland, Sch Med, Dept Epidemiol & Publ Hlth, 660 Redwood St,Howard Hall 100A, Baltimore, MD 21201 USA

[4] Harvard TH Chan Sch Publ Hlth, Dept Biostat, Boston, MA USA

[5] Univ Minnesota, Sch Publ Hlth, Div Epidemiol & Community Hlth, Minneapolis, MN USA

[6] Univ Minnesota, Masonic Canc Ctr, Minneapolis, MN USA

[7] Canc Council Victoria, Canc Epidemiol Ctr, Carlton, Vic, Australia

[8] Univ Melbourne, Ctr Mol Environm Genet & Analyt Epidemiol, Melbourne, Vic, Australia

[9] Cent Hosp Vasteras, Dept Surg, Vasteras, Sweden

[10] Cent Hosp Vasteras, Clin Res Ctr, Vasteras, Sweden

[11] Beckman Res Inst, Dept Populat Sci, Div Canc Etiol, Duarte, CA USA

[12] City Hope Natl Med Ctr, 1500 E Duarte Rd, Duarte, CA 91010 USA

[13] Maastricht Univ, GROW Sch Oncol & Dev Biol, Dept Epidemiol, Maastricht, Netherlands

[14] NCI, Div Canc Epidemiol & Genet, Dept Hlth & Human Serv, Bethesda, MD 20892 USA

[15] Harvard Med Sch, Brigham & Womens Hosp, Div Prevent Med, Dept Med, Boston, MA USA

[16] Brigham & Womens Hosp, Channing Div Network Med, Dept Med, Boston, MA USA

[17] Harvard Med Sch, Boston, MA USA

[18] Amer Canc Soc, Epidemiol Res Program, Atlanta, GA 30329 USA

[19] Fred Hutchinson Canc Res Ctr, Div Publ Hlth Sci, 1124 Columbia St, Seattle, WA 98104 USA

[20] Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA

[21] Canc Prevent Inst Calif, Fremont, CA USA

[22] Natl Canc Ctr, Epidemiol & Prevent Grp, Res Ctr Canc Prevent & Screening, Tokyo, Japan

[23] Univ Tokyo, Grad Sch Med, AXA Dept Hlth & Human Secur, Tokyo, Japan

[24] Univ Hawaii, Ctr Canc, Program Epidemiol, Honolulu, HI 96822 USA

[25] Fdn IRCCS Ist Nazl Tumori, Epidemiol & Prevent Unit, Milan, Italy

[26] Linkoping Univ, Dept Clin & Expt Med, Linkoping, Sweden

[27] Univ Toronto, Dalla Lana Sch Publ Hlth, Toronto, ON, Canada

[28] Washington Univ, Sch Med, Dept Surg, Div Publ Hlth Sci, St Louis, MO 63110 USA

[29] George Washington Univ, Milken Inst, Sch Publ Hlth, Dept Epidemiol & Biostat, Washington, DC USA

[30] Albert Einstein Coll Med, Dept Epidemiol & Populat Hlth, Bronx, NY 10467 USA

[31] NYU, Sch Med, Dept Environm Med, Div Epidemiol, New York, NY USA

[32] Karolinska Inst, Natl Inst Environm Med, Div Nutr Epidemiol, Stockholm, Sweden

[33] Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden

[34] Univ Tromso, Dept Community Med, Fac Hlth Sci, Tromso, Norway

[35] Canc Registry Norway, Dept Res, Oslo, Norway

[36] Folkhalsan Res Ctr, Genet Epidemiol Grp, Helsinki, Finland

来源：

INTERNATIONAL JOURNAL OF EPIDEMIOLOGY | 2016年 / 45卷 / 03期

关键词：

Alcohol; folate; breast cancer; estrogen receptor; progesterone receptor; pooled analyses; epidemiology; cohort study; DIETARY-FOLATE INTAKE; ONE-CARBON METABOLISM; POSTMENOPAUSAL WOMEN; PLASMA FOLATE; BETA-CAROTENE; VITAMIN-C; COHORT; METAANALYSIS; PREVENTION; RETINOL;

D O I：

10.1093/ije/dyv156

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

Background: Breast cancer aetiology may differ by estrogen receptor (ER) status. Associations of alcohol and folate intakes with risk of breast cancer defined by ER status were examined in pooled analyses of the primary data from 20 cohorts. Methods: During a maximum of 6-18 years of follow-up of 1 089 273 women, 21 624 ER+ and 5113 ER- breast cancers were identified. Study-specific multivariable relative risks (RRs) were calculated using Cox proportional hazards regression models and then combined using a random-effects model. Results: Alcohol consumption was positively associated with risk of ER+ and ER- breast cancer. The pooled multivariable RRs (95% confidence intervals) comparing >= 30 g/d with 0 g/day of alcohol consumption were 1.35 (1.23-1.48) for ER+ and 1.28 (1.10-1.49) for ER+ breast cancer (P-trend <= 0.001; Pcommon-effects by ER status: 0.57). Associations were similar for alcohol intake from beer, wine and liquor. The associations with alcohol intake did not vary significantly by total (from foods and supplements) folate intake (P-interaction >= 0.26). Dietary (from foods only) and total folate intakes were not associated with risk of overall, ER+ and ER- breast cancer; pooled multivariable RRs ranged from 0.98 to 1.02 comparing extreme quintiles. Following-up US studies through only the period before mandatory folic acid fortification did not change the results. The alcohol and folate associations did not vary by tumour subtypes defined by progesterone receptor status. Conclusions: Alcohol consumption was positively associated with risk of both ER+ and ER- breast cancer, even among women with high folate intake. Folate intake was not associated with breast cancer risk.

引用

页码：916 / 928

页数：13

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