OPTIMAL CONCENTRATIONS OF GADOVIST IN T1-WEIGHTED MAGNETIC RESONANCE IMAGING: PHANTOM STUDY AND COMPUTER SIMULATION

Contrast-Enhanced Magnetic Resonance Imaging (CE-MRI) has been widely used in the diagnosis of lesions. Many contrast agents with various chemical and pharmacokinetic properties have been developed for clinical use. The signal-to-noise ratio (SNR) and contrast-to-noise ratio (CNR) after the contrast agent administration depend on many factors, e. g. category and injected dosage of contrast agents, field strength of magnetic resonance (MR) scanner, slew rate of gradient, type of radiofrequency coil, reconstruction algorithm, pulse sequences, and so on. Gadovist is a newly developed contrast agent with high formulation of 1.0 M. It has been used in MR angiography and perfusion studies. The aim of this study is to investigate the optimal concentrations of Gadovist in MR T-1-weighted (T1W) images from phantom study and computer simulation. A phantom made of 21 test tubes with various concentrations of Gadovist (0-160 mM) was investigated. All the studies were performed on a 1.5-T clinical whole-body scanner. Four T1W pulse sequences, including two-dimensional spoiled gradient echo (2DSPGR), three-dimensional fast spoiled gradient echo (3DFSPGR), conventional spin echo (CSE), and inversion recovery (IR) were employed to produce T1W images. The CNR values were calculated from regions of interest (ROIs) of all test tubes and the optimal concentration for each pulse sequence was determined. The T-1 and T-2 values of the phantom were also measured to obtain the relaxivities (r(1) and r(2)). Afterward, the optimal concentration for each pulse sequence could be obtained from computer simulation by using the r(1) and r(2) values. The results showed that the measured optimal concentrations for 2DSPGR, 3DFSPGR, CSE and IR are 10, 20, 2.5, and 2.5 mM, respectively. The r(1) and r(2) values of the Gadovist phantom are 4.1 and 5.7 mM(-1)s(-1), respectively. The optimal concentrations obtained from computer simulation are 13.5, 22.8, 2.0, and 2.7 mM for 2DSPGR, 3DFSPGR, CSE, and IR, respectively. The optimal concentrations obtained from computer simulation and phantom study are in good agreement.