Predisposition to prolonged neutropenia after chemotherapy for paediatric acute myeloid leukaemia is associated with better prognosis in the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study

被引：4

作者：

Aoki, Takahiro ^{[1
]}

Takahashi, Hiroyuki ^{[2
]}

Tanaka, Shiro ^{[3
]}

Shiba, Norio ^{[4
]}

Hasegawa, Daiichiro ^{[5
]}

Iwamoto, Shotaro ^{[6
]}

Terui, Kiminori ^{[7
]}

Moritake, Hiroshi ^{[8
]}

Nakayama, Hideki ^{[9
]}

Shimada, Akira ^{[10
]}

Koh, Katsuyoshi ^{[11
]}

Goto, Hiroaki ^{[12
]}

Kosaka, Yoshiyuki ^{[5
]}

Saito, Akiko M. ^{[13
]}

Horibe, Keizo ^{[13
]}

Kinoshita, Akitoshi ^{[14
]}

Tawa, Akio ^{[15
]}

Taga, Takashi ^{[16
]}

Adachi, Souichi ^{[17
]}

Tomizawa, Daisuke ^{[18
]}

机构：

[1] Chiba Univ, Grad Sch Med, Dept Pediat, Chiba, Japan

[2] Toho Univ, Dept Pediat, Tokyo, Japan

[3] Kyoto Univ, Grad Sch Med, Dept Clin Biostat, Clin Biostat Course, Kyoto, Japan

[4] Yokohama City Univ Med, Grad Sch Med, Dept Pediat, Yokohama, Kanagawa, Japan

[5] Hyogo Prefectural Kobe Childrens Hosp, Dept Hematol Oncol, Kobe, Hyogo, Japan

[6] Mie Univ, Dept Pediat, Tsu, Mie, Japan

[7] Hirosaki Univ, Dept Pediat, Hirosaki, Aomori, Japan

[8] Univ Miyazaki, Fac Med, Div Pediat, Miyazaki, Japan

[9] Natl Hosp Org, Dept Pediat, Kyushu Canc Ctr, Fukuoka, Japan

[10] Okayama Univ Hosp, Dept Pediat Hematol Oncol, Okayama, Japan

[11] Saitama Childrens Med Ctr, Dept Hematol Oncol, Saitama, Japan

[12] Kanagawa Childrens Med Ctr, Div Hematol Oncol, Yokohama, Kanagawa, Japan

[13] Natl Hosp Org, Clin Res Ctr, Nagoya Med Ctr, Nagoya, Aichi, Japan

[14] St Marianna Univ, Sch Med, Dept Pediat, Kawasaki, Kanagawa, Japan

[15] Higashiosaka Aramoto Heiwa Clin, Higashiosaka, Osaka, Japan

[16] Shiga Univ Med Sci, Dept Pediat, Otsu, Shiga, Japan

[17] Kyoto Univ, Dept Human Hlth Sci, Kyoto, Japan

[18] Natl Ctr Child Hlth & Dev, Childrens Canc Ctr, Div Leukemia & Lymphoma, Tokyo, Japan

来源：

BRITISH JOURNAL OF HAEMATOLOGY | 2021年 / 193卷 / 01期

基金：

日本学术振兴会;

关键词：

acute myeloid leukaemia; chemosensitivity; children; myelosuppression; neutropenia; LYMPHOBLASTIC-LEUKEMIA; CHILDREN; RELAPSE; THERAPY;

D O I：

10.1111/bjh.16656

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The variability in myelosuppression after chemotherapy for acute myeloid leukaemia (AML) can affect its prognosis; however, the underlying mechanism remains controversial. In the Japanese Paediatric Leukaemia/Lymphoma Study Group AML-05 study, we showed that prolonged neutropenia was associated with high overall survival (P = 0 center dot 011) and low frequency of relapse (P = 0 center dot 042) in patients without granulocyte-colony stimulating factor (G-CSF) who completed the indicated treatment protocol. Our data indicate that predisposition to prolonged neutropenia after chemotherapy is correlated with a better outcome of AML treatment. Our results promote the usage of individualised drug dosing strategies to improve the therapeutic outcome in AML patients.

引用

页码：176 / 180

页数：5

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