Biomaterial-Mediated Delivery of Microenvironmental Cues for Repair and Regeneration of Articular Cartilage

被引：51

作者：

Toh, Wei Seong ^{[1
,2
]}

Spector, Myron ^{[1
,2
]}

Lee, Eng Hin ^{[3
]}

Cao, Tong ^{[4
]}

机构：

[1] VA Boston Healthcare Syst, Tissue Engn Labs, Boston, MA 02130 USA

[2] Harvard Univ, Sch Med, Brigham & Womens Hosp, Dept Orthopaed Surg, Boston, MA 02115 USA

[3] Natl Univ Singapore, Yong Loo Lin Sch Med, Dept Orthopaed Surg, Singapore 117510, Singapore

[4] Natl Univ Singapore, Fac Dent, Singapore 119083, Singapore

来源：

MOLECULAR PHARMACEUTICS | 2011年 / 8卷 / 04期

关键词：

biomaterials; delivery systems; cartilage; microenvironment; repair; regenerative medicine; tissue engineering; MESENCHYMAL STEM-CELLS; COLLAGEN-GAG SCAFFOLDS; AGE-RELATED-CHANGES; CHONDROCYTE IMPLANTATION; IN-VITRO; TISSUE; DEFECTS; BONE; MATRIX; CHONDROGENESIS;

D O I：

10.1021/mp100437a

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Articular cartilage injuries are one of the most challenging problems in musculoskeletal medicine due to the poor intrinsic regenerative capacity of this tissue. The lack of efficient treatment modalities motivates research into tissue engineering: combining cells, biomaterials mimicking extracellular matrix (scaffolds) and microenvironmental signaling cues. The, aim of this review is to focus on the use of biomaterials as delivery systems for microenvironmental cues in relation to their applications for treatment of cartilage defects. The latest advances in cartilage tissue engineering and regeneration are critically reviewed to demonstrate an outline of challenges toward biomaterial-based approaches of cartilage regeneration.

引用

页码：994 / 1001

页数：8

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