Glyphosate and AMPA in Human Urine of HBM4EU Aligned Studies: Part A Children

被引:15
|
作者
Buekers, Jurgen [1 ]
Remy, Sylvie [1 ]
Bessems, Jos [1 ]
Govarts, Eva [1 ]
Rambaud, Loic [2 ]
Riou, Margaux [2 ]
Tratnik, Janja Snoj [3 ]
Stajnko, Anja [3 ]
Katsonouri, Andromachi [4 ]
Makris, Konstantinos C. [5 ]
De Decker, Annelies [6 ]
Morrens, Bert [7 ]
Vogel, Nina [8 ]
Kolossa-Gehring, Marike [8 ]
Esteban-Lopez, Marta [9 ]
Castano, Argelia [9 ]
Andersen, Helle Raun [10 ]
Schoeters, Greet [1 ,11 ]
机构
[1] Flemish Inst Technol Res, Unit Hlth, VITO, B-2400 Mol, Belgium
[2] Sante Publ France, Dept Environm & Occupat Hlth, F-94415 St Maurice, France
[3] Jozef Stefan Inst, Dept Environm Sci, Ljubljana 1000, Slovenia
[4] Cyprus State Gen Lab, Minist Hlth, CY-2081 Nicosia, Cyprus
[5] Cyprus Univ Technol, Cyprus Int Inst Environm & Publ Hlth, CY-3036 Limassol, Cyprus
[6] Knowledge Ctr Environm & Hlth, PIH, B-2000 Antwerp, Belgium
[7] Univ Antwerp, Dept Social Sci, B-2000 Antwerp, Belgium
[8] German Environm Agcy UBA, D-06844 Berlin, Germany
[9] Inst Salud Carlos III, Natl Ctr Environm Hlth, Madrid 28220, Spain
[10] Univ Southern Denmark, Dept Publ Hlth, DK-5000 Odense, Denmark
[11] Univ Antwerp, Dept Biomed Sci, B-2610 Antwerp, Belgium
基金
欧盟地平线“2020”;
关键词
HBM4EU; glyphosate; AMPA; exposure; HBM; children; EXPOSURE;
D O I
10.3390/toxics10080470
中图分类号
X [环境科学、安全科学];
学科分类号
08 ; 0830 ;
摘要
Few data are available on the exposure of children to glyphosate (Gly) in Europe. Within HBM4EU, new HBM exposure data were collected from aligned studies at five sampling sites distributed over Europe (studies: SLO CRP (SI); ORGANIKO (CY); GerES V-sub (DE); 3XG (BE); ESTEBAN (FR)). Median Gly concentrations in urine were below or around the detection limit (0.1 mu g/L). The 95th percentiles ranged between 0.18 and 1.03 mu g Gly/L. The ratio of AMPA (aminomethylphosphonic acid; main metabolite of Gly) to Gly at molar basis was on average 2.2 and the ratio decreased with higher Gly concentrations, suggesting that other sources of AMPA, independent of metabolism of Gly to AMPA in the monitored participants, may concurrently operate. Using reverse dosimetry and HBM exposure data from five European countries (east, west and south Europe) combined with the proposed ADI (acceptable daily intake) of EFSA for Gly of 0.1 mg/kg bw/day (based on histopathological findings in the salivary gland of rats) indicated no human health risks for Gly in the studied populations at the moment. However, the absence of a group ADI for Gly+AMPA and ongoing discussions on e.g., endocrine disrupting effects cast some uncertainty in relation to the current single substance ADI for Gly. The carcinogenic effects of Gly are still debated in the scientific community. These outcomes would influence the risk conclusions presented here. Finally, regression analyses did not find clear associations between urinary exposure biomarkers and analyzed potential exposure determinants. More information from questionnaires targeting exposure-related behavior just before the sampling is needed.
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页数:14
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