Cytotoxic Diterpenoids from Scoparia dulcis

被引：1

作者：

Wang, Lirong ^{[1
]}

Yu, Jie ^{[2
]}

Nie, Zonglong ^{[2
]}

Shan, Peipei ^{[1
]}

机构：

[1] Qingdao Univ, Inst Translat Med, Coll Med, Affiliated Hosp, Qingdao 266021, Peoples R China

[2] Qingdao Cent Hosp, Qingdao 266042, Peoples R China

来源：

RECORDS OF NATURAL PRODUCTS | 2022年 / 16卷 / 05期

基金：

中国国家自然科学基金;

关键词：

Scoparia dulcis; Scrophulariaceae; scopadulane diterpenoid; labdane diterpenoid; cytotoxicity; SCOPADULCIC ACID; INHIBITOR; GLUCOSE; L;

D O I：

10.25135/rnp.304.2111.2266

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

A new scopadulane-type diterpenoid (1) and one known labdane-type diterpenoid (2) have been isolated from the whole plants of a traditional medicinal plant, Scoparia dulcis. Their structures were established mainly by spectroscopic methods, and the absolute configuration of compound 1 has been determined by quantum chemical calculation of the electronic circular dichroism (ECD) spectrum and comparison with the experimental one. The cytotoxicity of 1 and 2 against two breast cancer cell lines (MCF-7 and MDA-MB231) and a cervical cancer cell line (Hela) were tested, and only compound 2 displayed inhibitory activities against these cells with IC50 values ranging from 8.1 to 45.2 .M, while compound 1 were inactive. In addition, compound 2 also showed in vitro anti-tumor activity against MCF-7, MDA-MB231, and Hela cells in a concentration-dependent manner.

引用

页码：454 / 462

页数：9

共 50 条

[31] CONTRIBUTION TO EMBRYOLOGY OF SCOPARIA-DULCIS L
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