Synthesis and surface modification of magnetic nanoparticles for potential applications in sarcomas

被引:4
作者
Shahbazi, S. [1 ]
Wang, X. [2 ,3 ]
Yang, J. -L. [2 ,3 ]
Jiang, X. C. [1 ,4 ]
Ryan, R. [2 ,3 ]
Yu, A. B. [1 ,4 ]
机构
[1] Univ New S Wales, Sch Mat Sci & Engn, Sydney, NSW 2052, Australia
[2] Univ New S Wales, Fac Med, Prince Wales Clin Sch, Sarcoma & Nanooncol Grp,Adult Canc Program, Sydney, NSW 2052, Australia
[3] Univ New S Wales, Lowy Canc Res Ctr, Sydney, NSW 2052, Australia
[4] Monash Univ, Dept Chem Engn, Clayton, Vic 3168, Australia
关键词
Iron oxide nanoparticles; Surface modification; Sarcoma; Cytotoxicity; Cellular uptake; Nanomedicine; IRON-OXIDE NANOPARTICLES; MESOPOROUS SILICA NANOPARTICLES; IN-VIVO; FUNCTIONALIZATION; BIODISTRIBUTION; CHEMOTHERAPY; MITOXANTRONE; PROBES; MODEL;
D O I
10.1007/s11051-015-3065-7
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
The application of nano-science in cancer therapy has become one of the most attractive tools in scientific research because of its versatility in diagnosis and treatment. Among the different types of nanoparticles, iron oxide nanoparticles (IONPs) are renowned for their low toxicity and suitability for therapeutic and diagnostic, or 'theragnostic,' approach against different types of cancers. Research investigating the effect of IONPs with different physiochemical characteristics in sarcoma is limited. In this study, we initially prepared IONPs of different sizes (200, 100, 20, and 10 nm) and modified their surface with different types of coatings (polyethylene glycol, D-glucose, and silica) under mild conditions. Various methods were used to illustrate and quantify cellular uptake of magnetic nanoparticles in sarcoma cell lines. Finally, the safety of the uptaken nanoparticles on diverse human sarcoma cell lines was investigated and found that the readily available IONPs can be taken up by synovial sarcoma and liposarcoma cell lines in the selective histological tumor types; however, they seem highly toxic for fibrous histiocytoma and fibrosarcoma.
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页数:19
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