The immunotherapy significantly improved survival of non-small cell lung cancer patients, but it may cause immune-related adverse events, which are severe in less than 10% of cases. We report the case of one patient who developed myositis and myasthenia during nivolumab treatment for metastatic lung squamous carcinoma. Moreover, we reviewed literature data in order to identify similar cases in cancer patients treated with immune-checkpoints inhibitors. A 65-year-old patient, who had previously received a first-line platinum-based therapy, developed diplopia and ptosis 4 weeks after the start of nivolumab. Although antibodies associated with myositis, myasthenia gravis and paraneoplastic syndromes were absent, immune-related myositis and myasthenia were diagnosed. Corticosteroids, immunoglobulin and pyridostigmine showed poor efficacy and the patient died 7 weeks after the appearance of the first symptoms. Fifteen similar cases were found in the literature. A close collaboration between different specialists is essential to rapidly identify and treat severe immune-related adverse events.
机构:
King Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
King Abdul Aziz Med City, Div Neurol, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
Kojan, Suleiman
Alothman, Adel
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King Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
King Abdul Aziz Med City, Dept Med, Div Infect Dis, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
Alothman, Adel
Althani, Ziad
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机构:
King Abdul Aziz Med City, Div Neurol, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
Althani, Ziad
Alshehri, Ali
论文数: 0引用数: 0
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机构:
King Abdul Aziz Med City, Div Neurol, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
Alshehri, Ali
Mansour, Nouf
论文数: 0引用数: 0
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机构:
King Abdul Aziz Med City, Div Neurol, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
Mansour, Nouf
Khathaami, Ali
论文数: 0引用数: 0
h-index: 0
机构:
King Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
King Abdul Aziz Med City, Div Neurol, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
Khathaami, Ali
Haider, Abdulrazzaq
论文数: 0引用数: 0
h-index: 0
机构:
King Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
King Abdul Aziz Med City, Dept Pathol, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
Haider, Abdulrazzaq
Al-Jumah, Mohammed
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机构:
King Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
King Abdul Aziz Med City, Div Neurol, Riyadh, Saudi Arabia
King Abdullah Int Med Res Ctr, Riyadh, Saudi ArabiaKing Saud bin Abdulaziz Univ, Coll Med, Riyadh 11481, Saudi Arabia
机构:
Capital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R China
Yu, Hansong
Wang, Xiaoxiao
论文数: 0引用数: 0
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机构:
Capital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R China
Wang, Xiaoxiao
Pan, Yuetong
论文数: 0引用数: 0
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机构:
Capital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R China
Pan, Yuetong
Li, Hongyan
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机构:
Capital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R ChinaCapital Med Univ, Xuanwu Hosp, Gen Surg Dept, Beijing 100053, Peoples R China
机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Izumi, Hiroki
Kodani, Masahiro
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Kodani, Masahiro
Kurai, Jun
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Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Kurai, Jun
Takeda, Kenichi
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Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Takeda, Kenichi
Okazaki, Ryota
论文数: 0引用数: 0
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Okazaki, Ryota
Yamane, Kohei
论文数: 0引用数: 0
h-index: 0
机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Yamane, Kohei
Teruya, Yasuhiko
论文数: 0引用数: 0
h-index: 0
机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Teruya, Yasuhiko
Yamamoto, Akihiro
论文数: 0引用数: 0
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Yamamoto, Akihiro
Sueda, Yuriko
论文数: 0引用数: 0
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Sueda, Yuriko
Yanai, Masaaki
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Yanai, Masaaki
Tanaka, Natsumi
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Tanaka, Natsumi
Sakamoto, Tomohiro
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Sakamoto, Tomohiro
Yamaguchi, Kosuke
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Yamaguchi, Kosuke
Makino, Haruhiko
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Makino, Haruhiko
Igishi, Tadashi
论文数: 0引用数: 0
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
Igishi, Tadashi
Yamasaki, Akira
论文数: 0引用数: 0
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机构:
Tottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, JapanTottori Univ, Fac Med, Div Med Oncol & Mol Respirol, 36-1 Nishi Cho, Yonago, Tottori 6838504, Japan
机构:
Hiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Atom Bomb Survivors Hosp, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Yamasaki, Masahiro
Daido, Wakako
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Univ, Dept Mol & Internal Med, Grad Sch Biomed & Hlth Sci, Minami Ku, Hiroshima, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Daido, Wakako
Funaishi, Kunihiko
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Atom Bomb Survivors Hosp, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Funaishi, Kunihiko
Kawamoto, Kazuma
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Atom Bomb Survivors Hosp, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Kawamoto, Kazuma
Matsumoto, Yu
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Atom Bomb Survivors Hosp, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Matsumoto, Yu
Matsumoto, Naoko
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Atom Bomb Survivors Hosp, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Matsumoto, Naoko
Taniwaki, Masaya
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Atom Bomb Survivors Hosp, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Taniwaki, Masaya
Ohashi, Nobuyuki
论文数: 0引用数: 0
h-index: 0
机构:
Hiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Atom Bomb Survivors Hosp, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Ohashi Clin, Naka Ku, Hiroshima, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
Ohashi, Nobuyuki
Hattori, Noboru
论文数: 0引用数: 0
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机构:
Hiroshima Univ, Dept Mol & Internal Med, Grad Sch Biomed & Hlth Sci, Minami Ku, Hiroshima, JapanHiroshima Red Cross Hosp, Dept Resp Dis, Naka Ku, 1-9-6 Senda Machi, Hiroshima 7308619, Japan
机构:
Chonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea
Chonnam Natl Univ, Hwasun Hosp, Hwasun, South KoreaChonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea
Kim, Je-Seong
Nam, Tai-Seung
论文数: 0引用数: 0
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机构:
Chonnam Natl Univ, Med Sch, Dept Neurol, Gwangju, South Korea
Chonnam Natl Univ Hosp, Gwangju, South KoreaChonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea
Nam, Tai-Seung
Kim, Jieun
论文数: 0引用数: 0
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机构:
Chonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea
Chonnam Natl Univ, Hwasun Hosp, Hwasun, South KoreaChonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea
Kim, Jieun
Kho, Bo-Gun
论文数: 0引用数: 0
h-index: 0
机构:
Chonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea
Chonnam Natl Univ, Hwasun Hosp, Hwasun, South KoreaChonnam Natl Univ, Med Sch, Dept Internal Med, Hwasun, South Korea