Myositis and myasthenia during nivolumab administration for advanced lung cancer: a case report and review of the literature

被引:11
|
作者
Veccia, Antonello [1 ]
Kinspergher, Stefania [1 ]
Grego, Elisabetta [1 ]
Peterlana, Dimitri [2 ]
Berti, Alvise [3 ]
Tranquillini, Enzo
Caffo, Orazio [1 ]
机构
[1] Santa Chiara Hosp, Med Oncol, Largo Medaglie Oro 1, I-38122 Trento, Italy
[2] Santa Chiara Hosp, Internal Med, Trento, Italy
[3] Santa Chiara Hosp, Neurol, Trento, Italy
关键词
lung cancer; myasthenia; myositis; nivolumab; CELL; DOCETAXEL; COMPLICATIONS; GRAVIS;
D O I
10.1097/CAD.0000000000000903
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
The immunotherapy significantly improved survival of non-small cell lung cancer patients, but it may cause immune-related adverse events, which are severe in less than 10% of cases. We report the case of one patient who developed myositis and myasthenia during nivolumab treatment for metastatic lung squamous carcinoma. Moreover, we reviewed literature data in order to identify similar cases in cancer patients treated with immune-checkpoints inhibitors. A 65-year-old patient, who had previously received a first-line platinum-based therapy, developed diplopia and ptosis 4 weeks after the start of nivolumab. Although antibodies associated with myositis, myasthenia gravis and paraneoplastic syndromes were absent, immune-related myositis and myasthenia were diagnosed. Corticosteroids, immunoglobulin and pyridostigmine showed poor efficacy and the patient died 7 weeks after the appearance of the first symptoms. Fifteen similar cases were found in the literature. A close collaboration between different specialists is essential to rapidly identify and treat severe immune-related adverse events.
引用
收藏
页码:540 / 544
页数:5
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