Oxidative Phosphorylation of N-Aryl Glycine Amides via sp3 C-H Functionalization

被引：27

作者：

Jia, Xiaodong ^{[1
]}

Liu, Xiaofei ^{[2
]}

Shao, Yu ^{[3
]}

Yuan, Yu ^{[1
]}

Zhu, Yingzu ^{[2
]}

Hou, Wentao ^{[2
]}

Zhang, Xuewen ^{[1
]}

机构：

[1] Yangzhou Univ, Sch Chem & Chem Engn, Yangzhou 225002, Jiangsu, Peoples R China

[2] Northwest Normal Univ, Coll Chem & Chem Engn, Lanzhou 730070, Gansu, Peoples R China

[3] Yangzhou Univ, Sch Informat Engn, Yangzhou 225127, Jiangsu, Peoples R China

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2017年 / 359卷 / 24期

基金：

中国国家自然科学基金;

关键词：

Radical cation; C-H functionalization; Glycine; Phosphorylation; alpha-Aminophosphonate; AMINO-ACID DERIVATIVES; C-SP3-H FUNCTIONALIZATION; SUBSTITUTED QUINOLINES; PHOSPHONATION; BOND; ACTIVATION; CONSTRUCTION; CATALYSIS; SITE; ALKENYLATION;

D O I：

10.1002/adsc.201700850

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

An efficient phosphorylation of various glycine amides has been developed for radical cation salt-induced C-H functionalization, producing a series of alpha-aminophosphonates in high yields. Different from reported approaches, trialkyl phosphite was chosen as the phosphorus nucleophile, and the scope investigation shows broad functional group tolerance and high efficiency of the oxidative phosphorylation. This method provides a new way to synthesize alpha-aminophosphonates.

引用

页码：4399 / 4404

页数：6

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